UniProt Accession

 MAF1_HUMAN; Q9H063; D3DWL4 

Genbank Protein ID

 AL136937; CR533463; AC104592; CH471162; CH471162; BC014082; BC018714; BC031273 

Genbank Nucleotide ID

 CAB66871.1; CAG38494.1; EAW82158.1; EAW82159.1; AAH14082.1; AAH18714.1; AAH31273.1 

Protein Name

 Repressor of RNA polymerase III transcription MAF1 homolog 

Protein Synonyms/Alias

  

Gene Name

 MAF1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	LSPSRLSKSQGGEEE	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. 

Sequence Annotation

 MOD_RES 60 60 Phosphoserine; by MTOR.
 MOD_RES 64 64 Phosphothreonine.
 MOD_RES 65 65 Phosphoserine.
 MOD_RES 68 68 Phosphoserine; by MTOR.
 MOD_RES 70 70 Phosphoserine.
 MOD_RES 75 75 Phosphoserine; by MTOR.
 MOD_RES 212 212 Phosphothreonine.
 MOD_RES 214 214 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 256 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0060077; C:inhibitory synapse; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0001030; F:RNA polymerase III type 1 promoter DNA binding; IDA:UniProtKB.
 GO:0001031; F:RNA polymerase III type 2 promoter DNA binding; IDA:UniProtKB.
 GO:0001032; F:RNA polymerase III type 3 promoter DNA binding; IDA:UniProtKB.
 GO:0016480; P:negative regulation of transcription from RNA polymerase III promoter; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR015257; Maf1.
 IPR017152; RNA_pol_III_tscrpt_repres_MAF1. 

Pfam

 PF09174; Maf1 

SMART

  

PROSITE

  

PRINTS