UniProt Accession

 IMPCT_MOUSE; O55091; Q3UUR6; Q9EQH0 

Genbank Protein ID

 D87973; AF232228; BC020524; AK138136 

Genbank Nucleotide ID

 BAA35139.1; AAG23916.1; AAH20524.1; BAE23558.1 

Protein Name

 Protein IMPACT 

Protein Synonyms/Alias

 Imprinted and ancient gene protein 

Gene Name

 Impact 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
204	QVKLVLAKLYENKKI	ubiquitination	[1]
210	AKLYENKKIASATHN	ubiquitination	[1]
228	YRIFCEDKQTFLQDC	ubiquitination	[1]
291	ARNILVEKNFTNTPD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. 

Sequence Annotation

 DOMAIN 14 116 RWD.
 MOD_RES 137 137 Phosphoserine.  

Keyword

 Complete proteome; Phosphoprotein; Reference proteome; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0001933; P:negative regulation of protein phosphorylation; IDA:MGI.
 GO:0006446; P:regulation of translational initiation; IDA:MGI. 

Interpro

 IPR023582; Impact.
 IPR001498; Impact_N.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR006575; RWD-domain.
 IPR016135; UBQ-conjugating_enzyme/RWD.
 IPR020569; UPF0029_Impact_CS. 

Pfam

 PF05773; RWD
 PF01205; UPF0029 

SMART

 SM00591; RWD 

PROSITE

 PS50908; RWD
 PS00910; UPF0029 

PRINTS