CPLM-009401

Genbank Nucleotide ID

Heterogeneous nuclear ribonucleoprotein K

Protein Synonyms/Alias

hnRNP K; Transformation up-regulated nuclear protein; TUNP

Homo sapiens (Human)

Position	Peptide	Type	References
456	YLLQNSVKQYADVEG	ubiquitination	[1]

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

DOMAIN 42 104 KH 1.
REPEAT 54 76 1-1.
REPEAT 59 62 3-1.
DOMAIN 144 209 KH 2.
REPEAT 245 250 2-1.
REPEAT 257 260 3-2.
REPEAT 267 270 3-3.
REPEAT 295 298 3-4.
REPEAT 324 329 2-2.
DOMAIN 387 451 KH 3.
REPEAT 399 421 1-2.
REPEAT 404 407 3-5.
REGION 1 276 Necessary for interaction with DDX1.
REGION 35 197 Interaction with ASFV p30.
REGION 54 421 2 X 22 AA approximate repeats.
REGION 59 407 5 X 4 AA repeats of G-X-G-G.
REGION 209 337 Interaction with ZIK1 (By similarity).
REGION 236 273 RNA-binding RGG-box.
REGION 245 329 2 X 6 AA approximate repeats.
MOD_RES 1 1 N-acetylmethionine.
MOD_RES 116 116 Phosphoserine.
MOD_RES 214 214 Phosphoserine.
MOD_RES 216 216 Phosphoserine.
MOD_RES 284 284 Phosphoserine.
MOD_RES 379 379 Phosphoserine.
MOD_RES 380 380 Phosphotyrosine.
CROSSLNK 422 422 Glycyl lysine isopeptide (Lys-Gly)

3D-structure; Acetylation; Activator; Alternative splicing; Cell junction; Cell projection; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Glycoprotein; Host-virus interaction; Isopeptide bond; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Ribonucleoprotein; RNA-binding; Spliceosome; Transcription; Transcription regulation; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0042995; C:cell projection; IEA:UniProtKB-KW.
GO:0005737; C:cytoplasm; TAS:ProtInc.
GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
GO:0003723; F:RNA binding; TAS:ProtInc.
GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IMP:BHF-UCL.
GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IMP:BHF-UCL.
GO:0003697; F:single-stranded DNA binding; TAS:BHF-UCL.
GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB.
GO:0045716; P:positive regulation of low-density lipoprotein particle receptor biosynthetic process; IMP:BHF-UCL.
GO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:BHF-UCL.
GO:0072369; P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
GO:0010988; P:regulation of low-density lipoprotein particle clearance; IMP:BHF-UCL.
GO:0007165; P:signal transduction; TAS:ProtInc.
GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW.

IPR004087; KH_dom.
IPR004088; KH_dom_type_1.
IPR012987; ROK_N.

PF00013; KH_1
PF08067; ROKNT