CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013236
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongator complex protein 2 
Protein Synonyms/Alias
 ELP2; SHINC-2; STAT3-interacting protein 1; StIP1 
Gene Name
 Elp2 
Gene Synonyms/Alias
 Statip1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
255EDGSIRLKENTFTIKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Regulates the ligand-dependent activation of STAT3 (By similarity). 
Sequence Annotation
 REPEAT 56 100 WD 1.
 REPEAT 105 152 WD 2.
 REPEAT 160 200 WD 3.
 REPEAT 205 246 WD 4.
 REPEAT 280 328 WD 5.
 REPEAT 338 377 WD 6.
 REPEAT 385 424 WD 7.
 REPEAT 435 473 WD 8.
 REPEAT 563 607 WD 9.
 REPEAT 610 649 WD 10.
 REPEAT 665 704 WD 11.
 REPEAT 716 760 WD 12.
 REPEAT 773 821 WD 13.  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 821 AA 
Protein Sequence
MVSSVLEVSY VFCCPNRARG ALSWNSGPGG LLAFGTSCSV VLYDPQKKVV ITNLNGHTAR 60
VNCLHWIRTE DGSPSTELVS GASDNRVIHW ELENNQVLKS VRLQGHEGPV YAVHGIYQSG 120
PSDGEQHALI ASAASDSTVR LWSKKGSEVK CLQILKFGDG FVLTVCLSTL PDTDAPVLAC 180
GDDGGRIHLF VQQDDWFQKM LSLCGHEDWI RGVEWATFGR DLFLASCSQD CLIRIWRLYM 240
KPTSLETEDG SIRLKENTFT IKDGGVSTTV AVILETVLAG HENWVNAIHW QPSFYKDGVL 300
HQPVRLLSAS MDKTMILWAP DEESGVWLEQ VRVGEVGGNT LGFYGCQFGE NGSMIIAHAF 360
HGAMHLWKQS TVNPRQWAPE IVISGHFDGV QDLIWDPEGE FIITTSTDQT TRLFAPWKKK 420
NQSQVTWHEI ARPQIHGYNL KCLAMIDRFQ FVSGADEKVL RVFSAPRNFV ENFSVISRQS 480
LSHMLYDEDN DLPEGATVPA LGLSNKAVFE GDMTYLTSEE EELLSPAFGY PQVIFQPAVL 540
SEPPTEDHLL QNTLWPEVQK LYGHGYEIFC VTCNNSKTLL ASACKAAQKE HAAIILWSTT 600
SWKQVQSLAY HTLTVTQMAF SPDDKFLLAV SRDRTWSLWK RQDVTSAEFD PFFSLFAFTN 660
KITSVHSRII WSCDWSPDSK YFFTGSRDKK VVVWGECNSS YNPMEHPINP CSSILDVGSC 720
VTAVSVCPVL NPAQRYIVAV GLESGKICIY SWSKTNQETK DWTSCVETTP SQSHTLGIRR 780
LCWKSCSGST EQSEEGTEWL DFASCGEDHT VKIYRVNRCA L 821 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0033588; C:Elongator holoenzyme complex; ISS:UniProtKB.
 GO:0000502; C:proteasome complex; ISS:UniProtKB.
 GO:0008023; C:transcription elongation factor complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0061133; F:endopeptidase activator activity; ISS:UniProtKB.
 GO:0043248; P:proteasome assembly; ISS:UniProtKB.
 GO:0046425; P:regulation of JAK-STAT cascade; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB. 
Interpro
 IPR011047; Quinonprotein_ADH-like_supfam.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS