CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006726
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisome proliferator-activated receptor gamma 
Protein Synonyms/Alias
 PPAR-gamma; Nuclear receptor subfamily 1 group C member 3 
Gene Name
 Pparg 
Gene Synonyms/Alias
 Nr1c3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
77QEYQSAIKVEPASPPsumoylation[1]
Reference
 [1] Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines.
 Jennewein C, Kuhn AM, Schmidt MV, Meilladec-Jullig V, von Knethen A, Gonzalez FJ, Brüne B.
 J Immunol. 2008 Oct 15;181(8):5646-52. [PMID: 18832723] 
Functional Description
 Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses (By similarity). 
Sequence Annotation
 DNA_BIND 136 210 Nuclear receptor.
 ZN_FING 139 159 NR C4-type.
 ZN_FING 176 198 NR C4-type.
 REGION 205 280 Interaction with FAM120B.
 REGION 317 505 Ligand-binding (By similarity).
 MOD_RES 112 112 Phosphoserine; by MAPK (By similarity).
 CARBOHYD 84 84 O-linked (GlcNAc...).  
Keyword
 Activator; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Glycoprotein; Metal-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 505 AA 
Protein Sequence
MVDTEMPFWP TNFGISSVDL SVMEDHSHSF DIKPFTTVDF SSISAPHYED IPFTRADPMV 60
ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT QLYNRPHEEP SNSLMAIECR VCGDKASGFH 120
YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF 180
GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY IKSFPLTKAK ARAILTGKTT 240
DKSPFVIYDM NSLMMGEDKI KFKHITPLQE QSKEVAIRIF QGCQFRSVEA VQEITEYAKN 300
IPGFINLDLN DQVTLLKYGV HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKNLRKPFGD 360
FMEPKFEFAV KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK 420
LNHPESSQLF AKVLQKMTDL RQIVTEHVQL LHVIKKTETD MSLHPLLQEI YKDLY 475 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0050544; F:arachidonic acid binding; IDA:BHF-UCL.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; TAS:MGI.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:UniProtKB.
 GO:0001012; F:RNA polymerase II regulatory region DNA binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0050873; P:brown fat cell differentiation; IDA:MGI.
 GO:0045165; P:cell fate commitment; IGI:MGI.
 GO:0071285; P:cellular response to lithium ion; IDA:MGI.
 GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI.
 GO:0030855; P:epithelial cell differentiation; IGI:MGI.
 GO:0006954; P:inflammatory response; TAS:MGI.
 GO:0015909; P:long-chain fatty acid transport; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:1900077; P:negative regulation of cellular response to insulin stimulus; IMP:BHF-UCL.
 GO:0001818; P:negative regulation of cytokine production; IMP:BHF-UCL.
 GO:0090278; P:negative regulation of peptide hormone secretion; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0001890; P:placenta development; IMP:MGI.
 GO:0045600; P:positive regulation of fat cell differentiation; IEP:HGNC.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0032526; P:response to retinoic acid; IDA:UniProtKB.
 GO:0050872; P:white fat cell differentiation; IEP:HGNC. 
Interpro
 IPR003074; 1Cnucl_rcpt.
 IPR003077; 1Cnucl_rcpt_G.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR022590; PPARgamma_N.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF12577; PPARgamma_N
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR01288; PROXISOMEPAR.
 PR01291; PROXISOMPAGR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.