CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033858
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Vitamin D 25-hydroxylase 
Protein Synonyms/Alias
  
Gene Name
 Cyp2r1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
144RRPSWEYKCKMPYTEubiquitination[1]
223DSNGYFTKKEALIPFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 290 AA 
Protein Sequence
MLELPGARAC AGALAGALLL LLFVLVVRQL LRQRRPAGFP PGPPRLPFVG NICSLALSAD 60
LPHVYMRKQS RVYGEIFSLD LGGISTVVLN GYDVVKECLV HQSEIFADRP CLPLFMKMTK 120
MGGQVHKEID LIVGHNRRPS WEYKCKMPYT EAVLHEVLRF CNIVPLGIFH ATSEDAVVRG 180
YSIPKGTTVI TNLYSVHFDE KYWKDPDMFY PERFLDSNGY FTKKEALIPF SLGRRHCLGE 240
QLARMEMFLF FTSLLQQFHL HFPHELVPNL KPRLGMTLQP QPYLICAERR 290 
Gene Ontology
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
 GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
 GO:0030343; F:vitamin D3 25-hydroxylase activity; IDA:MGI. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002403; Cyt_P450_E_grp-IV. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00465; EP450IV.
 PR00385; P450.