CPLM-005705

Genbank Nucleotide ID

CUGBP Elav-like family member 1

Protein Synonyms/Alias

CELF-1; 50 kDa nuclear polyadenylated RNA-binding protein; Brain protein F41; Bruno-like protein 2; CUG triplet repeat RNA-binding protein 1; CUG-BP1; CUG-BP- and ETR-3-like factor 1; Deadenylation factor CUG-BP; Deadenylation factor EDEN-BP; Embryo deadenylation element-binding protein homolog; EDEN-BP homolog; RNA-binding protein BRUNOL-2

Brunol2; Cugbp; Cugbp1

Mus musculus (Mouse)

Position	Peptide	Type	References
44	QPDLDAIKMFVGQVP	ubiquitination	[1]
57	VPRTWSEKDLRELFE	ubiquitination	[1]
97	FVTFYTRKAALEAQN	ubiquitination	[1]
193	TMAQTAIKAMHQAQT	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition (By similarity). Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Promotes exclusion of exon 11 of the INSR pre-mRNA (By similarity). Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast (By similarity). Increases translation and controls the choice of translation initiation codon of CEBPB mRNA (By similarity). Increases mRNA translation of CEBPB in aging liver. Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3 (By similarity). Mediates rapid cytoplasmic mRNA deadenylation (By similarity). Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation (By similarity). Required for completion of spermatogenesis. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs) (By similarity). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA (By similarity). Binds to the 5'-region of CDKN1A and CEBPB mRNAs (By similarity). Binds with the 5'-region of CEBPB mRNA in aging liver.

DOMAIN 16 99 RRM 1.
DOMAIN 108 188 RRM 2.
DOMAIN 401 479 RRM 3.
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 302 302 Phosphoserine.

Acetylation; Activator; Alternative splicing; Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005737; C:cytoplasm; IDA:MGI.
GO:0005634; C:nucleus; IDA:MGI.
GO:0042835; F:BRE binding; ISS:UniProtKB.
GO:0003729; F:mRNA binding; IEA:Compara.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0031369; F:translation initiation factor binding; IDA:MGI.
GO:0006376; P:mRNA splice site selection; IDA:MGI.
GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
GO:0007286; P:spermatid development; IMP:MGI.

IPR012677; Nucleotide-bd_a/b_plait.
IPR000504; RRM_dom.