CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025279
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 
Protein Synonyms/Alias
 Branched chain ketoacid dehydrogenase E1, alpha polypeptide 
Gene Name
 Bckdha 
Gene Synonyms/Alias
 mCG_7651 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
105LPQEEVLKFYRSMTLacetylation[1]
199MPVHYGCKERHFVTIacetylation[1]
312FAVYNATKEARRRAVacetylation[1]
357DEVNYWDKQDHPISRacetylation[1]
357DEVNYWDKQDHPISRubiquitination[2]
381WWDEEQEKAWRKQSRacetylation[1]
401AFEQAERKLKPNPSLacetylation[1]
446YPLDHFDK*******acetylation[3, 4]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 446 AA 
Protein Sequence
MAIVMSAAKI WRPSRGLRQA ALLLLGRSGV RGLARSHPSR QQQQQFPSLD DKPQFPGASA 60
EFVDKLEFIQ PNVISGIPIY RVMDRQGQII NPSEDPHLPQ EEVLKFYRSM TLLNTMDRIL 120
YESQRQGRIS FYMTNYGEEG THVGSAAALE RTDLVFGQYR EAGVLMYRDY PLELFMSQCY 180
GNVNDPGKGR QMPVHYGCKE RHFVTISSPL ATQIPQAVGA AYAAKRANAN RIVICYFGEG 240
AASEGDAHAG FNFAATLECP IIFFCRNNGY AISTPTSEQY RGDGIAARGP GYGIMSIRVD 300
GNDVFAVYNA TKEARRRAVA ENQPFLIEAM TYRIGHHSTS DDSSAYRSVD EVNYWDKQDH 360
PISRLRQYLL NQGWWDEEQE KAWRKQSRKK VMEAFEQAER KLKPNPSLLF SDVYQEMPAQ 420
LRRQQESLAR HLQTYGEHYP LDHFDK 446 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara. 
Interpro
 IPR001017; DH_E1. 
Pfam
 PF00676; E1_dh 
SMART
  
PROSITE
  
PRINTS