CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015437
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protocadherin-23 
Protein Synonyms/Alias
 Cadherin-27; Cadherin-like protein CDHJ; Cadherin-like protein VR8; Protein dachsous homolog 2; Protocadherin PCDHJ 
Gene Name
 DCHS2 
Gene Synonyms/Alias
 CDH27; CDHJ; PCDH23; PCDHJ 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2747SILADVRKESVFISGmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 Calcium-dependent cell-adhesion protein (By similarity). 
Sequence Annotation
 DOMAIN 56 177 Cadherin 1.
 DOMAIN 178 382 Cadherin 2.
 DOMAIN 378 480 Cadherin 3.
 DOMAIN 481 583 Cadherin 4.
 DOMAIN 586 692 Cadherin 5.
 DOMAIN 693 839 Cadherin 6.
 DOMAIN 844 960 Cadherin 7.
 DOMAIN 949 1055 Cadherin 8.
 DOMAIN 1056 1165 Cadherin 9.
 DOMAIN 1165 1269 Cadherin 10.
 DOMAIN 1270 1374 Cadherin 11.
 DOMAIN 1375 1478 Cadherin 12.
 DOMAIN 1479 1583 Cadherin 13.
 DOMAIN 1584 1685 Cadherin 14.
 DOMAIN 1685 1787 Cadherin 15.
 DOMAIN 1788 1892 Cadherin 16.
 DOMAIN 1892 1992 Cadherin 17.
 DOMAIN 1993 2094 Cadherin 18.
 DOMAIN 2095 2210 Cadherin 19.
 DOMAIN 2211 2314 Cadherin 20.
 DOMAIN 2315 2425 Cadherin 21.
 DOMAIN 2426 2533 Cadherin 22.
 CARBOHYD 220 220 N-linked (GlcNAc...) (Potential).
 CARBOHYD 245 245 N-linked (GlcNAc...) (Potential).
 CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
 CARBOHYD 467 467 N-linked (GlcNAc...) (Potential).
 CARBOHYD 539 539 N-linked (GlcNAc...) (Potential).
 CARBOHYD 673 673 N-linked (GlcNAc...) (Potential).
 CARBOHYD 820 820 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1032 1032 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1140 1140 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1209 1209 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1443 1443 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1599 1599 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1615 1615 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1874 1874 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2024 2024 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2042 2042 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2100 2100 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2209 2209 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2474 2474 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2522 2522 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2635 2635 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Calcium; Cell adhesion; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2916 AA 
Protein Sequence
MRLDEITKSE NEDGEKKMFT QQFESTDACV YEVYVKINSI VKSQSQCGLK RGSPETELWG 60
AIVFRSQEEN AKPVKETEVT ASDADSGLYG FIEYSLYDGF LSYEAPQAFR IDPHDGQICV 120
SQDIDRERDP ATYDLLVEAK DGDEQRMTHL ALVKGGLSAQ AFVRVDLEDV NDNHPVFNPS 180
TYVTSISDET QPGTEIINVL ATDQDSGIYG TVAYELIPGN VSSLFTIDST TGLYSPEVEI 240
LSAVNFSADK EVMNSLEMFL PLLRHFKKVE RDEEAAEKKF EASRGWFMRF KGRRHLHYLK 300
VQDEAASADG EAAARYVANL AKILGEGIIY LTLPLSHLES TTLSLMVSAQ DGGGLTAVIN 360
ADVTIHIFQT TLAPAEFERP KYTFLVYEDV PEDSPIGTVK AREPLNSSEP IFYRISSGDL 420
GGKFSIHPRL GTIRTRKPLD HETQPVVVLT VQAQLGSAPA CSSTEVNITV MDVNDNHPAF 480
LRTSDEIRIS QTTPPGTALY LARAEDRDSG RNGLIRYSIA SPQPGVFAID RALGVLFLNG 540
SLGAGEQREL TLTLRAEDQG VHPQAALLVL TVVIEKREHS PSWTFEHLVY QVEVSESLSP 600
MTQMLQTQAH PLGPQRAASP LRYSLEPSVD SAMFGIRPYT GWIYLRRQFD YESTQTYNFR 660
VFAWIPEDGF LQNVSTTVIV RVWDENDNSP TFLHDVLFLK VEESPVPQGV IGKITAIDMD 720
SGKNGQLLYF LLSDGKFFKM NPNTGPAGTI YVITWADGAA AFSGTDFAFS SDELQAFVLK 780
SLFCELGEGE LINWVALDRE HRGHHEMTVL VTDRGSPPRN ATMAVYVSVT DINDNRPFFP 840
QCLPGKELHV KVLEGQPVNM LVTTVFAKDP DEGNNAEVTY SVSSEDSSDH FKIDANNGEI 900
RTTTILSYDY RPSYRMSVIA TDQGVPPLQG QAVVNIQVIP LSKGRAIMSQ NIRHLIIPEN 960
LKPTKIMSLI KSSDHLQQHY NGKLHFSIVA DDKDGHFEID SSTGDLFLSK ELDYETTSHY 1020
LFRVITTDHS KNLSLSSTVF LSIDVEDQND HSPSFQDELI VISVEENVPI GTLVYVFNAK 1080
DDDGSFLNSR IQYYIESHNP GTNPFLIHPS FGTLVTVSRL DRESIPTVIL TVTASDQAVN 1140
VTDRRLRSLT AQIVILDVND HNPTFISFPN AHVKEDVTVG SLVHHITAHD PDEGRNGKVT 1200
YSILSGNENM TFMLDESSGL LTTTCPLDYE MKTQHILTVL ALDDGTPALS SSQTLTVTVL 1260
DVNDEAPVFK QHLYEASVKE NQNPGEFVTR VEALDRDSGV NSKLQFEIMP GASFELFEIN 1320
SDTGEVVTTT ILDREIQEVF TLRVLVRDGG FPSLSSTTTI LCTVEDENDH APEFIVSSYD 1380
IEVLENQEPE VVYTVLASDM DAGNNRAVEY HIIDGNTDEC FTINEMSGEL STTRALDREQ 1440
ISNFTLVILC SDLGDPPRSS VIHLQVRVLD ANDHSPSFPT LYYQSSVRED AEVGTVVLVL 1500
SAVDKDEGLN GQTEYFLTDE ASGAFTIDPM SGTLKTSNTL DREARSQHTF SAVARDCSIQ 1560
GSRSTTVIIK VYVTDVNDND PVLEQNPFDV FLSPESPTNQ TTVIVRADDL DLGPNGTVVF 1620
SFAETQSMFS IDKYTGEIQF QQNPSSEYFP IWLQLKVTDQ GIPARTTTGL LVIHMEGEDV 1680
KISFSHHLYK GLVTENCEAG TSIVTVKAFA PDSIQDSMKY SIFSGNEDGV LSLCSKSGQL 1740
TVKEPKFLDF EVRNEVQLIV LAESSGHRAY CKVAVLIQDE NDNSPCFEQS IYQASVSESQ 1800
LYNAHVIQVF ATDLDSGLNG LIEYSILSGN QEEAFQIDAL SGVITTKAIL DYELTSSYSL 1860
IVQATDKGMP RLSNTTVIKV QVTDINDNAP AFLPSEAVEI TEDSLPGVIV THVSVHDVDL 1920
NSAFIFSFAK ESNPGTKFAI DQNTGVVVLV KTLDFEEMTE YELLIQISDS VHYTEGALVV 1980
RVLDVNDNPP VFSQDFYQVT VPESIPVGYS VLTLSATDLE SNENISYRIL SSSKEFSIDP 2040
KNGTIFTISP VLLLDTISTT QFLVEASDGG NPDLRALTLV EIGIEDMNNY APEFTVKSYN 2100
LSLSEDALVG STLVTFSNID HDWTRENTYV EYSIISGNSQ NNFHVETKFF HSEYPYKQVG 2160
YLVLLHSLDR EASASHELVI LASDSGCPPL SSTAVISIQV LDVNDNPPNF SSLSYHTHVK 2220
ESTPLGSHIT VVSANDRDTG SHAEIIYNII SGNEKGHFYL EENTGVLYLI KPLDYEKMTK 2280
FTLTVQASDA EKKHFSFAVV FVSVLDDNDH APQFMFSSFS CIVPENLPIS STICSINALD 2340
FDAGPYGELT YSIVSPCFLT HGMSYDHDLF LIDPLTGDIH AKQILDYENG NKYCLTVQAK 2400
DKGDATASLV VWVDIEGIDE FEPIFTQDQY FFTLPEKNKD RQLIGRVEAS DADAGIDGVI 2460
LYSLGTSSPF FSVNKTNGNI YLIRALPLIK SQLNKEDTLE MKIIAHSPKS DSKFASCTVF 2520
VNVSFSSEGT PLAVFASSFS ISLVVSFLVF LILICILIVM ILRHKQKDTI NNYEEKKTSS 2580
LDADLRVTRD ASVLKAFQKT DDCSNEVVPV DATPEWLSLI SIMEKDIVNL YRHSNSSGHC 2640
SVEGETAEDK EIQRINEHPY RKCSDSALSD HESRVPDSGI PRDSDQLSCL SGETDVMVTA 2700
ETAEASQTFG EGDQGEGCST TCAQNNVLPQ TVQKREAKES ILADVRKESV FISGDQEVRC 2760
AALSTQTTSD HDGKDNYHWN YLLSWEPKFQ PLASVFNDIA KLKDEHLHMP GIPKEKKSFV 2820
FPPPLITAVA QPGIKAVPPR MPAVNLGQVP PKHPRSPIPY HLGSLPEGMT PNFSPSLSLL 2880
TMQPPALSPL LREGELLGTH ISGTCHELKA EDEVQI 2916 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS. 
Pfam
 PF00028; Cadherin 
SMART
 SM00112; CA 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.