CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014690
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coatomer subunit delta 
Protein Synonyms/Alias
 Archain; Delta-coat protein; Delta-COP 
Gene Name
 Arcn1 
Gene Synonyms/Alias
 Copd 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
233LKLGAKGKEVDNFVDacetylation[1]
309MLRISDDKFGRIRLHacetylation[1]
347AESLIGLKNPEKSFPacetylation[1]
351IGLKNPEKSFPVNSDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). 
Sequence Annotation
 DOMAIN 271 511 MHD.
 MOD_RES 233 233 N6-acetyllysine (By similarity).
 MOD_RES 309 309 N6-acetyllysine (By similarity).
 MOD_RES 493 493 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 511 AA 
Protein Sequence
MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE TESVRYVYQP 60
MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN EISEHCFDLI FAFDEIVALG 120
YRENVNLAQI RTFTEMDSHE EKVFRAVRET QEREAKAEMR RKAKELQQAR RDAERQGKKA 180
PGFGGFGSSA VSGGSTAAMI TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD 240
KLKSEGETIM SSNMGKRTSE AAKVHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM 300
IMLRISDDKF GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE KSFPVNSDVG 360
VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED NLELNDVVIT IPLPSGVGAP 420
VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK SGSLEFSIPG QPNDFFPVQV SFISKKNYCN 480
IQVTKVTQVD GNSPVRFSTE TTFLVDKYEI L 511 
Gene Ontology
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0030126; C:COPI vesicle coat; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IEA:InterPro. 
Interpro
 IPR022775; AP_mu_sigma_su.
 IPR008968; Clathrin_mu_C.
 IPR027059; Coatomer_dsu.
 IPR011012; Longin-like_dom. 
Pfam
 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 
SMART
  
PROSITE
 PS51072; MHD 
PRINTS