CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036227
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 BRCA1-A complex subunit Abraxas 
Protein Synonyms/Alias
  
Gene Name
 FAM175A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106RLEHSLYKPQKGLFHubiquitination[1]
109HSLYKPQKGLFHRVPubiquitination[1, 2, 3, 4]
152AVQTHSSKFFEEDGSubiquitination[1, 2, 4, 5]
161FEEDGSLKEVHKINEubiquitination[1, 4]
219QIQAAREKNIQKDPQubiquitination[1, 4]
223AREKNIQKDPQENIFubiquitination[4]
253HSCVMSLKNRHVSKSubiquitination[1, 4]
296ASTPQIIKHKALDLDubiquitination[3]
298TPQIIKHKALDLDDRubiquitination[1, 2, 4, 5]
309LDDRWQFKRSRLLDTubiquitination[2, 4]
319RLLDTQDKRSKADTGubiquitination[4]
335SNQDKASKMSSPETDubiquitination[4, 5]
347ETDEEIEKMKGFGEYubiquitination[4, 5]
349DEEIEKMKGFGEYSRubiquitination[1, 4, 5]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MDDVEVVYTI DIQKYIPCYQ LFSFYNSSGE VNEQALKKIL SNVKKNVVGW YKFRRHSDQI 60
MTFRERLLHK NLQEHFSNQD LVFLLLTPSI ITESCSTHRL EHSLYKPQKG LFHRVPLVVA 120
NLGMSEQLGY KTVSGSCMST GFSRAVQTHS SKFFEEDGSL KEVHKINEMY ASLQEELKSI 180
CKKVEDSEQA VDKLVKDVNR LKREIEKRRG AQIQAAREKN IQKDPQENIF LCQALRTFFP 240
NSEFLHSCVM SLKNRHVSKS SCNYNHHLDV VDNLTLMVEH TDIPEASPAS TPQIIKHKAL 300
DLDDRWQFKR SRLLDTQDKR SKADTGSSNQ DKASKMSSPE TDEEIEKMKG FGEYSRSPTF 360 
Gene Ontology
  
Interpro
 IPR023238; FAM175.
 IPR023239; FAM175_BRCA1-A_cplx_Abraxas_su. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR02052; ABRAXAS.
 PR02051; PROTEINF175.