UniProt Accession

 RALY_HUMAN; Q9UKM9; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3 

Genbank Protein ID

 AF148457; L38696; AL031668; AL031668; BC105018 

Genbank Nucleotide ID

 AAF04487.1; AAC28898.1; CAI22150.1; CAB43742.1; AAI05019.1 

Protein Name

 RNA-binding protein Raly 

Protein Synonyms/Alias

 Autoantigen p542; Heterogeneous nuclear ribonucleoprotein C-like 2; hnRNP core protein C-like 2; hnRNP associated with lethal yellow protein homolog 

Gene Name

 RALY 

Gene Synonyms/Alias

 HNRPCL2; P542 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
34	NLNTALVKKSDVETI	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Probable-RNA binding protein. Could be a heterogeneous nuclear ribonucleoprotein (hnRNP). May be involved in pre-mRNA splicing (By similarity). 

Sequence Annotation

 DOMAIN 21 92 RRM.
 REGION 227 253 Epitope (recognized by BKRF1 antibodies).
 MOD_RES 106 106 Phosphoserine.
 MOD_RES 135 135 Phosphoserine.
 MOD_RES 165 165 N6-acetyllysine.
 MOD_RES 262 262 Phosphothreonine (By similarity).
 MOD_RES 264 264 Phosphoserine (By similarity).
 MOD_RES 286 286 Phosphothreonine.
 MOD_RES 288 288 Phosphoserine.
 MOD_RES 295 295 Phosphoserine.
 MOD_RES 298 298 Phosphothreonine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 306 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB. 

Interpro

 IPR017347; hnRNP_C_Raly.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS