UniProt Accession

 CENPV_HUMAN; Q7Z7K6; B2RPK2; Q3L8N5; Q8NFH6 

Genbank Protein ID

 AY382899; BC052604; BC137486; BC137487; AF514992 

Genbank Nucleotide ID

 AAR24368.1; AAH52604.1; AAI37487.1; AAI37488.1; AAM76703.1 

Protein Name

 Centromere protein V 

Protein Synonyms/Alias

 CENP-V; Nuclear protein p30; Proline-rich protein 6 

Gene Name

 CENPV 

Gene Synonyms/Alias

 PRR6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	VEKPPSEKPRLRRSS	acetylation	[1]
123	ERWETFQKRQKLTSE	ubiquitination	[2]
147	FEYQGLVKHTGGCHC	ubiquitination	[1]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. 

Sequence Annotation

 MOD_RES 21 21 Phosphoserine.  

Keyword

 Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinetochore; Mitosis; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 275 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0000776; C:kinetochore; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0051233; C:spindle midzone; IDA:UniProtKB.
 GO:0016846; F:carbon-sulfur lyase activity; IEA:InterPro.
 GO:0001667; P:ameboidal cell migration; IDA:MGI.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0031508; P:centromeric heterochromatin assembly; IMP:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB.
 GO:0033044; P:regulation of chromosome organization; IMP:UniProtKB. 

Interpro

 IPR006913; GFA/CENP-V.
 IPR011057; Mss4-like. 

Pfam

 PF04828; GFA 

SMART

  

PROSITE

  

PRINTS