CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000162
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Microsomal triglyceride transfer protein large subunit 
Protein Synonyms/Alias
  
Gene Name
 Mttp 
Gene Synonyms/Alias
 Mtp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
271GPRMIPGKQVAGVIKubiquitination[1]
352LQILKAEKKEVLPQLacetylation[2]
609HNYDRFSKSGSSSAYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets. 
Sequence Annotation
 DOMAIN 28 658 Vitellogenin.  
Keyword
 Alternative promoter usage; Cholesterol metabolism; Complete proteome; Disulfide bond; Endoplasmic reticulum; Golgi apparatus; Lipid metabolism; Lipid-binding; Reference proteome; Signal; Steroid metabolism; Sterol metabolism; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 894 AA 
Protein Sequence
MILLAVLFLC FFSSYSASVK GHTTGLSLNN ERLYKLTYST EVFLDGGKGK PQDSVGYKIS 60
SDVDVVLLWR NPDGDDDQVI QVTITAVNVE NAGQQRGEKS IFQGKSTPKI IGKDNLEALQ 120
RPMLLHLVRG KVKEFYSYEN EPVGIENLKR GLASLFQMQL SSGTTNEVDI SGDCKVTYQA 180
QQDKVVKIKA LDTCKIERSG FTTANQVLGV SSKATSVTTY KIEDSFVTAV LAEETRAFAL 240
NFQQTIAGKI VSKQKLELKT TEAGPRMIPG KQVAGVIKAV DSKYKAIPIV GQVLERVCKG 300
CPSLAEHWKS IRKNLEPENL SKAEAVQSFL AFIQHLRTSR REEILQILKA EKKEVLPQLV 360
DAVTSAQTPD SLEAILDFLD FKSDSSIILQ ERFLYACGFA THPDEELLRA LLSKFKGSFA 420
SNDIRESVMI IIGALVRKLC QNEGCKLKAV VEAKKLILGG LEKPEKKEDT TMYLLALKNA 480
LLPEGIPLLL KYAEAGEGPV SHLATTVLQR YDVSFITDEV KKTLNRIYHQ NRKVHEKTVR 540
TTAAAVILKN PSYMDVKNIL LSIGELPKEM NKYMLTVVQD ILHFEMPASK MIRRVLKEMA 600
VHNYDRFSKS GSSSAYTGYV ERSPRAASTY SLDILYSGSG ILRRSNLNIF QYIGKAELHG 660
SQVVIEAQGL EGLIAATPDE GEENLDSYAG MSAILFDVQL RPVTFFNGYS DLMSKMLSAS 720
GDPVSVVKGL ILLIDHSQDI QLQSGLKANM EIQGGLAIDI SGSMEFSLWY RESKTRVKNR 780
VAVVITSDVT VDASFVKAGV ESRAETEAGL EFISTVQFSQ YPFLVCMQMD KAEAPLRQFE 840
TKYERLSTGR GYVSRRRKES LVAGCELPLH QENSEMCNVV FPPQPESDNS GGWF 894 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0031988; C:membrane-bounded vesicle; IEA:Compara.
 GO:0031528; C:microvillus membrane; IEA:Compara.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0005319; F:lipid transporter activity; IDA:MGI.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
 GO:0042953; P:lipoprotein transport; IDA:MGI.
 GO:0006497; P:protein lipidation; IDA:MGI.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IDA:MGI. 
Interpro
 IPR015819; Lipid_transp_b-sht_shell.
 IPR001747; Lipid_transpt_N.
 IPR015816; Vitellinogen_b-sht_N.
 IPR011030; Vitellinogen_superhlx. 
Pfam
 PF01347; Vitellogenin_N 
SMART
 SM00638; LPD_N 
PROSITE
 PS51211; VITELLOGENIN 
PRINTS