CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037361
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transporter 
Protein Synonyms/Alias
  
Gene Name
 SLC6A6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
275PGAGAGIKFYLYPDIubiquitination[1, 2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEAEGKPPQ REKWSSKIDF VLSVAGGFVG 60
LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEII IGQYTSEGGI TCWEKICPLF 120
SGIGYASVVI VSLLNVYYIV ILAWATYYLF QSFQKELPWA HCNHSWNTPH CMEDTMRKNK 180
SVWITISSTN FTSPVIEFWE RNVLSLSPGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR 240
STGKVVYFTA TFPFAMLLVL LVRGLTLPGA GAGIKFYLYP DITRLEDPQV WIDAGTQIFF 300
SYAICLGAMT SLGSYNKYKY NSYRSWPGLH CLPKSCDNDA AAHILVHSFF YYASLAWTG 359 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
 GO:0005369; F:taurine:sodium symporter activity; IEA:InterPro. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR002434; Na/ntran_symport_taurine. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR00176; NANEUSMPORT.
 PR01200; TAUTRANSPORT.