CPLM-010942

Genbank Nucleotide ID

Pro-neuregulin-1, membrane-bound isoform

Protein Synonyms/Alias

Pro-NRG1; Neuregulin-1; Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; Glial growth factor; Heregulin; HRG; Neu differentiation factor; Sensory and motor neuron-derived factor

GGF; HGL; HRGA; NDF; SMDF

Homo sapiens (Human)

Position	Peptide	Type	References
43	PPRLKEMKSQESAAG	acetylation	[1]

[1] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]

Functional Description

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

DOMAIN 37 128 Ig-like C2-type.
DOMAIN 178 222 EGF-like.
CARBOHYD 120 120 N-linked (GlcNAc...) (Potential).
CARBOHYD 126 126 N-linked (GlcNAc...) (Potential).
CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
DISULFID 57 112 By similarity.
DISULFID 182 196
DISULFID 190 210
DISULFID 212 221

3D-structure; Alternative splicing; Cell membrane; Chromosomal rearrangement; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Glycoprotein; Growth factor; Immunoglobulin domain; Membrane; Nucleus; Polymorphism; Reference proteome; Secreted; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0016324; C:apical plasma membrane; IDA:BHF-UCL.
GO:0005737; C:cytoplasm; IEA:Compara.
GO:0005576; C:extracellular region; NAS:UniProtKB.
GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO:0005887; C:integral to plasma membrane; IEA:Compara.
GO:0016020; C:membrane; NAS:UniProtKB.
GO:0031594; C:neuromuscular junction; IEA:Compara.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005125; F:cytokine activity; TAS:BHF-UCL.
GO:0043125; F:ErbB-3 class receptor binding; IDA:BHF-UCL.
GO:0008083; F:growth factor activity; IDA:BHF-UCL.
GO:0030296; F:protein tyrosine kinase activator activity; IDA:BHF-UCL.
GO:0030971; F:receptor tyrosine kinase binding; NAS:UniProtKB.
GO:0003712; F:transcription cofactor activity; IDA:MGI.
GO:0030297; F:transmembrane receptor protein tyrosine kinase activator activity; IC:BHF-UCL.
GO:0003161; P:cardiac conduction system development; IEA:Compara.
GO:0060379; P:cardiac muscle cell myoblast differentiation; IDA:BHF-UCL.
GO:0016477; P:cell migration; IEA:Compara.
GO:0000902; P:cell morphogenesis; IEA:Compara.
GO:0008283; P:cell proliferation; IDA:BHF-UCL.
GO:0043624; P:cellular protein complex disassembly; IGI:MGI.
GO:0009790; P:embryo development; IEA:InterPro.
GO:0060956; P:endocardial cell differentiation; IDA:BHF-UCL.
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
GO:0010001; P:glial cell differentiation; IEA:Compara.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0007626; P:locomotory behavior; IEA:Compara.
GO:0030879; P:mammary gland development; TAS:BHF-UCL.
GO:0000165; P:MAPK cascade; IEA:Compara.
GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IDA:BHF-UCL.
GO:0042177; P:negative regulation of protein catabolic process; IEA:Compara.
GO:0051048; P:negative regulation of secretion; IDA:BHF-UCL.
GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.
GO:0007399; P:nervous system development; TAS:BHF-UCL.
GO:0014032; P:neural crest cell development; TAS:BHF-UCL.
GO:0048663; P:neuron fate commitment; IEA:Compara.
GO:0045213; P:neurotransmitter receptor metabolic process; IEA:Compara.
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
GO:0007422; P:peripheral nervous system development; IEA:Compara.
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IDA:BHF-UCL.
GO:0045785; P:positive regulation of cell adhesion; IDA:BHF-UCL.
GO:0030307; P:positive regulation of cell growth; IDA:BHF-UCL.
GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara.
GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Compara.
GO:0051155; P:positive regulation of striated muscle cell differentiation; ISS:BHF-UCL.
GO:0043497; P:regulation of protein heterodimerization activity; IDA:BHF-UCL.
GO:0043496; P:regulation of protein homodimerization activity; TAS:BHF-UCL.
GO:0007416; P:synapse assembly; IEA:Compara.
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IDA:BHF-UCL.
GO:0055012; P:ventricular cardiac muscle cell differentiation; IDA:BHF-UCL.
GO:0003222; P:ventricular trabecula myocardium morphogenesis; IDA:BHF-UCL.
GO:0042060; P:wound healing; IDA:BHF-UCL.

IPR000742; EG-like_dom.
IPR013032; EGF-like_CS.
IPR007110; Ig-like_dom.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR018250; Neuregulin.
IPR002154; Neuregulin_1_C.

PF12661; hEGF
PF07679; I-set
PF02158; Neuregulin

SM00181; EGF
SM00408; IGc2

PS00022; EGF_1
PS01186; EGF_2
PS50026; EGF_3
PS50835; IG_LIKE

PR01089; NEUREGULIN.