UniProt Accession

 TRBM_MOUSE; P15306 

Genbank Protein ID

 X14432; BC019154 

Genbank Nucleotide ID

 CAA32597.1; AAH19154.1 

Protein Name

 Thrombomodulin 

Protein Synonyms/Alias

 TM; Fetomodulin; CD141 

Gene Name

 Thbd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
555	ARAELEYKCASSAKE	ubiquitination	[1]
561	YKCASSAKEVVLQHV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. 

Sequence Annotation

 DOMAIN 31 167 C-type lectin.
 DOMAIN 240 280 EGF-like 1.
 DOMAIN 283 323 EGF-like 2.
 DOMAIN 324 362 EGF-like 3; calcium-binding (Potential).
 DOMAIN 364 404 EGF-like 4.
 DOMAIN 403 439 EGF-like 5.
 DOMAIN 440 480 EGF-like 6; calcium-binding (Potential).
 CARBOHYD 113 113 N-linked (GlcNAc...).
 CARBOHYD 243 243 N-linked (GlcNAc...) (Potential).
 CARBOHYD 256 256 N-linked (GlcNAc...) (Potential).
 CARBOHYD 408 408 N-linked (GlcNAc...) (Potential).
 CARBOHYD 494 494 O-linked (Xyl...) (glycosaminoglycan) (By
 DISULFID 135 156 By similarity.
 DISULFID 244 255 By similarity.
 DISULFID 251 264 By similarity.
 DISULFID 266 279 By similarity.
 DISULFID 287 295 By similarity.
 DISULFID 291 307 By similarity.
 DISULFID 309 322 By similarity.
 DISULFID 328 339 By similarity.
 DISULFID 335 348 By similarity.
 DISULFID 350 361 By similarity.
 DISULFID 368 377 By similarity.
 DISULFID 373 387 By similarity.
 DISULFID 389 403 By similarity.
 DISULFID 407 416 By similarity.
 DISULFID 412 424 By similarity.
 DISULFID 426 438 By similarity.
 DISULFID 444 454 By similarity.
 DISULFID 449 463 By similarity.
 DISULFID 465 479 By similarity.  

Keyword

 Blood coagulation; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Hemostasis; Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 577 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO:0007596; P:blood coagulation; TAS:MGI.
 GO:0009790; P:embryo development; IMP:MGI.
 GO:0007565; P:female pregnancy; IMP:MGI.
 GO:0050819; P:negative regulation of coagulation; TAS:MGI. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR016316; CD93/CD141.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR001491; Thrombomodulin.
 IPR015149; Tme5_EGF-like. 

Pfam

 PF07645; EGF_CA
 PF00059; Lectin_C
 PF09064; Tme5_EGF_like 

SMART

 SM00034; CLECT
 SM00181; EGF
 SM00179; EGF_CA 

PROSITE

 PS00010; ASX_HYDROXYL
 PS50041; C_TYPE_LECTIN_2
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA 

PRINTS

 PR00907; THRMBOMODULN.