UniProt Accession

 CLIC4_RAT; Q9Z0W7 

Genbank Protein ID

 AF104119 

Genbank Nucleotide ID

 AAD16875.1 

Protein Name

 Chloride intracellular channel protein 4 

Protein Synonyms/Alias

 Intracellular chloride ion channel protein p64H1 

Gene Name

 Clic4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
199	LPKLHIVKVVAKKYR	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. May play a role in angiogenesis (By similarity). 

Sequence Annotation

 DOMAIN 104 244 GST C-terminal.
 REGION 2 101 Required for insertion into the membrane
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 4 4 Phosphoserine (By similarity).
 MOD_RES 130 130 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Cell membrane; Chloride; Chloride channel; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; Ion channel; Ion transport; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 253 AA 

Protein Sequence

Gene Ontology

 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; TAS:UniProtKB.
 GO:0016021; C:integral to membrane; TAS:RGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0031982; C:vesicle; TAS:UniProtKB.
 GO:0005254; F:chloride channel activity; IDA:RGD.
 GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
 GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR002946; Int_Cl_channel.
 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

 PS50405; GST_CTER 

PRINTS

 PR01263; INTCLCHANNEL.