| Tag | Content |
|---|
| CPLM ID | CPLM-013417 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nuclear receptor subfamily 2 group C member 1 |
Protein Synonyms/Alias | Orphan nuclear receptor TR2; Testicular receptor 2; mTR2 |
Gene Name | Nr2c1 |
Gene Synonyms/Alias | Tr2; Tr2-11 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 238 | NIHPSGIKTEPAMLM | sumoylation | [1] |
|
Reference | [1] SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Park SW, Hu X, Gupta P, Lin YP, Ha SG, Wei LN. Nat Struct Mol Biol. 2007 Jan;14(1):68-75. [ PMID: 17187077] |
Functional Description | Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. |
Sequence Annotation | DNA_BIND 98 173 Nuclear receptor.
ZN_FING 101 121 NR C4-type.
ZN_FING 137 156 NR C4-type.
REGION 1 166 Required for interaction with KAT2B.
REGION 571 590 Required for interaction with NRIP1.
MOD_RES 185 185 Phosphoserine.
MOD_RES 203 203 Phosphoserine.
MOD_RES 208 208 Phosphothreonine.
MOD_RES 210 210 Phosphothreonine; by MAPK1.
MOD_RES 461 461 Phosphoserine; by PKC.
MOD_RES 568 568 Phosphoserine; by PKC.
CROSSLNK 238 238 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Activator; Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 590 AA |
Protein Sequence | MATIEEIAHQ IIDQQMGEIV TEQQTGQKIQ IVTALDHSTQ GKQFILANHE GSTPGKVFLT 60
TPDAAGVNQL FFTSPDLSAP HLQLLTEKSP DQGPNKVFDL CVVCGDKASG RHYGAITCEG 120
CKGFFKRSIR KNLVYSCRGS KDCVINKHHR NRCQYCRLQR CIAFGMKQDS VQCERKPIEV 180
SREKSSNCAA STEKIYIRKD LRSPLAATPT FVTDSETARS AGLLDSGMFV NIHPSGIKTE 240
PAMLMAPDKA ESCQGDLSTL ASVVTSLANL GKAKDLSHCG GDMPVVQSLR NGDTSFGAFH 300
HDIQTNGDVS RAFDTLAKAL TPGESSACQS PEEGMEGSPH LIAGEPSFVE KEGPLLSESH 360
VAFRLTMPSP MPEYLNVHYI GESASRLLFL SMHWALSIPS FQALGQENSI SLVKAYWNEL 420
FTLGLAQCWQ VMNVATILAT FVNCLHSSLQ QDKMSPERRK SLMEHIFKLQ EFCNSMVKLC 480
IDGHEYAYLK AIVLFSPDHP GLENMELIER FQEKAYVEFQ DYITRTYPDD TYRLSRLLLR 540
LPALRLMNAT ITEELFFKGL IGNVRIDSVI PHILKMEPAD YNSQIIGHSL 590 |
Gene Ontology | GO:0016605; C:PML body; IDA:UniProtKB. GO:0003677; F:DNA binding; IDA:UniProtKB. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0003707; F:steroid hormone receptor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB. GO:0048386; P:positive regulation of retinoic acid receptor signaling pathway; IDA:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |