UniProt Accession

 EVL_HUMAN; Q9UI08; A8K105; O95884; Q7Z522; Q8TBV1; Q9UF25; Q9UIC2 

Genbank Protein ID

 AF052504; AF087843; AF112209; AK289720; CH471061; BC023997; BC032358; AF131766; AL133642 

Genbank Nucleotide ID

 AAF21709.1; AAP97156.1; AAF17197.1; BAF82409.1; EAW81684.1; AAH23997.1; AAH32358.1; AAD20040.1; CAB63763.2 

Protein Name

 Ena/VASP-like protein 

Protein Synonyms/Alias

 Ena/vasodilator-stimulated phosphoprotein-like 

Gene Name

 EVL 

Gene Synonyms/Alias

 RNB6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	SKKWVPIKPGQQGFS	ubiquitination	[1]
367	SQPHSRMKPAGSVND	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. 

Sequence Annotation

 DOMAIN 1 112 WH1.
 REGION 222 413 EVH2.
 REGION 222 242 EVH2 block A.
 REGION 265 282 EVH2 block B.
 REGION 379 413 EVH2 block C.
 MOTIF 231 234 KLKR.
 MOD_RES 246 246 Phosphoserine.
 MOD_RES 304 304 Phosphoserine.
 MOD_RES 306 306 Phosphoserine.
 MOD_RES 329 329 Phosphoserine.
 MOD_RES 331 331 Phosphoserine.
 MOD_RES 341 341 Phosphoserine.
 MOD_RES 345 345 Phosphoserine (By similarity).
 MOD_RES 349 349 Phosphoserine.
 MOD_RES 354 354 Phosphoserine.
 MOD_RES 369 369 Phosphoserine.  

Keyword

 Actin-binding; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome; SH3-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005925; C:focal adhesion; ISS:UniProtKB.
 GO:0030027; C:lamellipodium; ISS:UniProtKB.
 GO:0005522; F:profilin binding; ISS:UniProtKB.
 GO:0017124; F:SH3 domain binding; ISS:UniProtKB.
 GO:0008154; P:actin polymerization or depolymerization; ISS:UniProtKB.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007166; P:cell surface receptor signaling pathway; NAS:UniProtKB.
 GO:0009887; P:organ morphogenesis; NAS:UniProtKB.
 GO:0051289; P:protein homotetramerization; IEA:InterPro. 

Interpro

 IPR000697; EVH1.
 IPR011993; PH_like_dom.
 IPR017354; Vasodilator_phosphoprotein.
 IPR014885; VASP_tetra. 

Pfam

 PF08776; VASP_tetra
 PF00568; WH1 

SMART

 SM00461; WH1 

PROSITE

 PS50229; WH1 

PRINTS