CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037672
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Torsin-1A-interacting protein 1 
Protein Synonyms/Alias
  
Gene Name
 TOR1AIP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
174DLSQTISKKTVRSIQubiquitination[1]
212EATSVQQKVNFSEEGubiquitination[2]
237HSSVTTVKARSRDSDubiquitination[1, 2, 3]
275QNFTAHDKQPSVLSSubiquitination[4, 5]
286VLSSGYQKTPQEWAPubiquitination[4, 5]
309MQNDSILKSELGNQSubiquitination[1, 2, 4, 5, 6]
335PQNASFVKRNRWWLLubiquitination[1, 4, 5, 6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 415 AA 
Protein Sequence
MAGDGRRAEA VREGWGVYVT PRAPIREGRG RLAPQNGGSS DAPAYRTPPS RQGRREVRFS 60
DEPPEVYGDF EPLVAKERSP VGKRTRLEEF RSDSAKEEVR ESAYYLRSRQ RRQPRPQETE 120
EMKTRRTTRL QQQHSEQPPL QPSPVMTRRG LRDSHSSEED EASSQTDLSQ TISKKTVRSI 180
QEAPAVSEDL VIRLRRPPLR YPRYEATSVQ QKVNFSEEGE TEEDDQDSSH SSVTTVKARS 240
RDSDESGDKT TRSSSQYIES FWQSSQSQNF TAHDKQPSVL SSGYQKTPQE WAPQTARIRT 300
RMQNDSILKS ELGNQSPSTS SRQVTGQPQN ASFVKRNRWW LLPLIAALAS GSFWFFSTPE 360
VETTAVQEFQ NQMNQLKNKY QGQDEKLWKR SQTFLEKHLN SSHPRSQPAI LLLTA 415 
Gene Ontology
  
Interpro
 IPR008662; Lamina-ass_polypeptide_CLAP1C. 
Pfam
 PF05609; LAP1C 
SMART
  
PROSITE
  
PRINTS