UniProt Accession

 SBK1_HUMAN; Q52WX2 

Genbank Protein ID

 AY874862 

Genbank Nucleotide ID

 AAX59898.1 

Protein Name

 Serine/threonine-protein kinase SBK1 

Protein Synonyms/Alias

 SH3-binding kinase 1 

Gene Name

 SBK1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	LAASDVTKHYELVRE	ubiquitination	[1, 2]
66	LGKGTYGKVDLVVYK	ubiquitination	[1]
73	KVDLVVYKGTGTKMA	ubiquitination	[1]
176	QLVHRDIKPENVLLF	ubiquitination	[1]
191	DRECRRVKLADFGMT	ubiquitination	[1]
352	LEAPGPLKRTVLTES	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May be involved in signal-transduction pathways related to the control of brain development (By similarity). 

Sequence Annotation

 DOMAIN 53 318 Protein kinase.
 NP_BIND 59 67 ATP (By similarity).
 ACT_SITE 174 174 Proton acceptor (By similarity).
 BINDING 82 82 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 424 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR016234; Ser/Thr_kinase_Sbk1. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS