| Tag | Content |
|---|
| CPLM ID | CPLM-018059 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TBC domain-containing protein kinase-like protein |
Protein Synonyms/Alias | |
Gene Name | TBCK |
Gene Synonyms/Alias | TBCKL; HSPC302 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 271 | PDQLMKDKVFSEVSP | ubiquitination | [1] | | 285 | PLYTPFTKPASLFSS | ubiquitination | [1] | | 343 | LEKELVNKEIIRSKP | ubiquitination | [1] | | 349 | NKEIIRSKPPICTLP | ubiquitination | [1] | | 433 | LPLIIREKDTEYQLN | ubiquitination | [1] | | 450 | ILFDRLLKAYPYKKN | ubiquitination | [1] | | 456 | LKAYPYKKNQIWKEA | ubiquitination | [1] | | 461 | YKKNQIWKEARVDIP | ubiquitination | [1] | | 495 | AKYDAIDKDTPIPTD | ubiquitination | [1] | | 706 | NLFCWTPKSATYRQH | ubiquitination | [1] | | 756 | SIPLNDLKSEVSPRI | ubiquitination | [1] | | 879 | ILDGGINKIKPTGLL | ubiquitination | [1] | | 881 | DGGINKIKPTGLLTI | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | |
Sequence Annotation | DOMAIN 1 273 Protein kinase.
DOMAIN 466 651 Rab-GAP TBC.
DOMAIN 790 889 Rhodanese. |
Keyword | Alternative splicing; Complete proteome; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 893 AA |
Protein Sequence | MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60
RGKHERLVVV AEHCERSLED LLRERKPVSC STVLCIAFEV LQGLQYMNKH GIVHRALSPH 120
NILLDRKGHI KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIFKTT DHMPSKKPLP 180
SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLD CVDDTLIVLA EEHGCLDIIK 240
ELPETVIDLL NKCLTFHPSK RPTPDQLMKD KVFSEVSPLY TPFTKPASLF SSSLRCADLT 300
LPEDISQLCK DINNDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF 360
EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420
SAAATLPLII REKDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480
GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540
DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600
IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660
AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKPS 720
SDSSGGRSSA PYFSAECPDP PKTDLSRESI PLNDLKSEVS PRISAEDLID LCELTVTGHF 780
KTPSKKTKSS KPKLLVVDIR NSEDFIRGHI SGSINIPFSA AFTAEGELTQ GPYTAMLQNF 840
KGKVIVIVGH VAKHTAEFAA HLVKMKYPRI CILDGGINKI KPTGLLTIPS PQI 893 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0005524; F:ATP binding; IEA:InterPro. GO:0005097; F:Rab GTPase activator activity; IEA:InterPro. GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro. GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |