UniProt Accession

 TIM8B_MOUSE; P62077; Q3TF77; Q9QUT4 

Genbank Protein ID

 AF196314; AK003382; AK004190; AK012925; AK169258; AK018718; AK019422; BC029239 

Genbank Nucleotide ID

 AAF13228.1; BAB22753.1; BAB23213.1; BAB28552.1; BAE41021.1; BAB31364.1; BAB31713.1; AAH29239.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit Tim8 B 

Protein Synonyms/Alias

 Deafness dystonia protein 2 homolog 

Gene Name

 Timm8b 

Gene Synonyms/Alias

 Ddp2; Tim8b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	CWDKCVEKPGSRLDS	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). 

Sequence Annotation

 MOTIF 36 59 Twin CX3C motif.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 DISULFID 36 59 By similarity.
 DISULFID 40 55 By similarity.  

Keyword

 Acetylation; Chaperone; Complete proteome; Disulfide bond; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Protein transport; Reference proteome; Translocation; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 83 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR004217; Tim10/DDP_fam_Znf. 

Pfam

 PF02953; zf-Tim10_DDP 

SMART

  

PROSITE

  

PRINTS