UniProt Accession

 ANXA4_HUMAN; P09525; Q96F33; Q9BWK1 

Genbank Protein ID

 M19383; M82809; D78152; AC019206; AC092431; AC112787; BC000182; BC011659 

Genbank Nucleotide ID

 AAC41689.1; AAA51740.1; BAA11227.1; AAH00182.1; AAH11659.1 

Protein Name

 Annexin A4 

Protein Synonyms/Alias

 35-beta calcimedin; Annexin IV; Annexin-4; Carbohydrate-binding protein p33/p41; Chromobindin-4; Endonexin I; Lipocortin IV; P32.5; PP4-X; Placental anticoagulant protein II; PAP-II; Protein II 

Gene Name

 ANXA4 

Gene Synonyms/Alias

 ANX4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
184	DLYEAGEKKWGTDEV	ubiquitination	[1]
213	LHVFDEYKRISQKDI	acetylation	[2]
225	KDIEQSIKSETSGSF	acetylation	[2]
293	HFKRLYGKSLYSFIK	acetylation	[2]
293	HFKRLYGKSLYSFIK	ubiquitination	[3]
300	KSLYSFIKGDTSGDY	acetylation	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (By similarity). 

Sequence Annotation

 REPEAT 23 83 Annexin 1.
 REPEAT 95 155 Annexin 2.
 REPEAT 179 239 Annexin 3.
 REPEAT 254 314 Annexin 4.
 MOD_RES 7 7 Phosphothreonine (By similarity).
 MOD_RES 213 213 N6-acetyllysine.
 MOD_RES 293 293 N6-acetyllysine.
 MOD_RES 300 300 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:UniProtKB.
 GO:0005509; F:calcium ion binding; NAS:UniProtKB.
 GO:0005544; F:calcium-dependent phospholipid binding; IDA:UniProtKB.
 GO:0004859; F:phospholipase inhibitor activity; NAS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.
 GO:0007165; P:signal transduction; TAS:UniProtKB. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002391; AnnexinIV. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.