UniProt Accession

 HBB1_MOUSE; P02088; Q54AI0; Q91V86; Q9CRZ2; Q9CXH5; Q9CY12; Q9CY54; Q9R0S6 

Genbank Protein ID

 X14061; J00413; AB020013; AB020015; AK002258; AK002394; AK003096; AK003472; AK005442; AK005490; AK005496; AK010873; AK010902; AK010980; AK010981; AK010991; AK010993; AK011006; AK011013; AK011016; AK011027; AK011033; AK011050; AK011052; AK011053; AK011057; AK011067; AK011069; AK011075; AK011077; AK011083; AK011102; AK012551; AK014364; AK027903; AK027904; AK028067; AK088149; AK133714; AK147001; AK160629; AK161021; AK165490; AK167615; AK168412; AK168477; AK168562; AK168584; AK168819; AK168826; AK168846; M19236; M10828; M10830; M10829; M10688 

Genbank Nucleotide ID

 CAA32224.1; AAA37791.1; BAA77353.1; BAA77355.1; BAB21971.1; BAB22067.1; BAB22562.1; BAB22806.1; BAB24036.1; BAB24075.1; BAB24080.1; BAB27237.1; BAB27255.1; BAB27302.1; BAB27303.1; BAB27310.1; BAB27312.1; BAB27325.1; BAB27331.1; BAB27334.1; BAB27343.1; BAB27347.1; BAB27360.1; BAB27361.1; BAB27362.1; BAB27365.1; BAB27374.1; BAB27376.1; BAB27380.1; BAB27382.1; BAB27387.1; BAB27399.1; BAB28311.1; BAB29299.1; BAC25655.1; BAC25656.1; BAC25734.1; BAC40173.1; BAE21794.1; BAE27598.1; BAE35926.1; BAE36152.1; BAE38217.1; BAE39668.1; BAE40327.1; BAE40366.1; BAE40435.1; BAE40453.1; BAE40646.1; BAE40653.1; BAE40669.1; AAA37788.1; AAA37786.1; AAA37787.1; AAA37787.1; AAA37790.1 

Protein Name

 Hemoglobin subunit beta-1 

Protein Synonyms/Alias

 Beta-1-globin; Hemoglobin beta-1 chain; Hemoglobin beta-major chain 

Gene Name

 Hbb-b1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	VHLTDAEKAAVSCLW	ubiquitination	[1]
18	AVSCLWGKVNSDEVG	acetylation	[2, 3]
18	AVSCLWGKVNSDEVG	succinylation	[3]
18	AVSCLWGKVNSDEVG	ubiquitination	[1]
133	AAQAAFQKVVAGVAT	acetylation	[2]
145	VATALAHKYH*****	acetylation	[2, 4]
145	VATALAHKYH*****	phosphoglycerylation	[5]
145	VATALAHKYH*****	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [5] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237] 

Functional Description

 Involved in oxygen transport from the lung to the various peripheral tissues. 

Sequence Annotation

 METAL 64 64 Iron (heme distal ligand).
 METAL 93 93 Iron (heme proximal ligand).
 MOD_RES 45 45 Phosphoserine.
 MOD_RES 81 81 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport; Phosphoprotein; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005833; C:hemoglobin complex; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IEA:InterPro.
 GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. 

Interpro

 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002337; Haemoglobin_b. 

Pfam

 PF00042; Globin 

SMART

  

PROSITE

 PS01033; GLOBIN 

PRINTS

 PR00814; BETAHAEM.