UniProt Accession

 E5RJ37_HUMAN; E5RJ37 

Genbank Protein ID

 AC018607; AC046176 

Genbank Nucleotide ID

  

Protein Name

 Tyrosine-protein kinase Lyn 

Protein Synonyms/Alias

  

Gene Name

 LYN 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
9	GCIKSKGKDSLSDDG	ubiquitination	[1]
20	SDDGVDLKTQPVRNT	ubiquitination	[1, 2, 3]
101	EEHGEWWKAKSLLTK	ubiquitination	[4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 150 AA 

Protein Sequence

Gene Ontology

 GO:0034666; C:alpha2-beta1 integrin complex; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0030061; C:mitochondrial crista; IEA:Compara.
 GO:0005758; C:mitochondrial intermembrane space; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0043208; F:glycosphingolipid binding; IEA:Compara.
 GO:0004713; F:protein tyrosine kinase activity; IEA:Compara.
 GO:0001782; P:B cell homeostasis; IEA:Compara.
 GO:0050853; P:B cell receptor signaling pathway; IEA:Compara.
 GO:0031668; P:cellular response to extracellular stimulus; IEA:Compara.
 GO:0034605; P:cellular response to heat; IEA:Compara.
 GO:0050663; P:cytokine secretion; IEA:Compara.
 GO:0097028; P:dendritic cell differentiation; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; IEA:Compara.
 GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; IEA:Compara.
 GO:0002553; P:histamine secretion by mast cell; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:Compara.
 GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara.
 GO:0030889; P:negative regulation of B cell proliferation; IEA:Compara.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0043407; P:negative regulation of MAP kinase activity; IEA:Compara.
 GO:0070667; P:negative regulation of mast cell proliferation; IEA:Compara.
 GO:0002762; P:negative regulation of myeloid leukocyte differentiation; IEA:Compara.
 GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; IEA:Compara.
 GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IEA:Compara.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0014003; P:oligodendrocyte development; IEA:Compara.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0002576; P:platelet degranulation; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:2000670; P:positive regulation of dendritic cell apoptotic process; IEA:Compara.
 GO:0060369; P:positive regulation of Fc receptor mediated stimulatory signaling pathway; IEA:Compara.
 GO:0060252; P:positive regulation of glial cell proliferation; IEA:Compara.
 GO:0070447; P:positive regulation of oligodendrocyte progenitor proliferation; IEA:Compara.
 GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Compara.
 GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0002902; P:regulation of B cell apoptotic process; IEA:Compara.
 GO:0050855; P:regulation of B cell receptor signaling pathway; IEA:Compara.
 GO:0050707; P:regulation of cytokine secretion; IEA:Compara.
 GO:0045646; P:regulation of erythrocyte differentiation; IEA:Compara.
 GO:0050727; P:regulation of inflammatory response; IEA:Compara.
 GO:0043304; P:regulation of mast cell degranulation; IEA:Compara.
 GO:0090330; P:regulation of platelet aggregation; IEA:Compara.
 GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0009743; P:response to carbohydrate stimulus; IEA:Compara.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0006991; P:response to sterol depletion; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0002513; P:tolerance induction to self antigen; IEA:Compara. 

Interpro

 IPR001452; SH3_domain. 

Pfam

 PF00018; SH3_1 

SMART

 SM00326; SH3 

PROSITE

 PS50002; SH3 

PRINTS

 PR00452; SH3DOMAIN.