| Tag | Content |
|---|
| CPLM ID | CPLM-001381 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Formimidoyltransferase-cyclodeaminase |
Protein Synonyms/Alias | 58 kDa microtubule-binding protein; Formiminotransferase-cyclodeaminase; FTCD; Glutamate formimidoyltransferase; Glutamate formiminotransferase; Glutamate formyltransferase; Formimidoyltetrahydrofolate cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase |
Gene Name | Ftcd |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 427 | LGAIKLPKNTPEERD | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity). |
Sequence Annotation | REGION 1 181 Formiminotransferase N-subdomain.
REGION 163 172 Folate binding (Potential).
REGION 182 326 Formiminotransferase C-subdomain.
REGION 327 334 Linker.
REGION 335 541 Cyclodeaminase/cyclohydrolase.
ACT_SITE 82 82 For formimidoyltransferase activity (By
ACT_SITE 412 412 For cyclodeaminase activity (Probable).
MOD_RES 519 519 Phosphoserine (By similarity). |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Folate-binding; Golgi apparatus; Histidine metabolism; Lyase; Multifunctional enzyme; Phosphoprotein; Pyridoxal phosphate; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 541 AA |
Protein Sequence | MSQLVECVPN FSEGNNQEVI DAISQAISQT PGCVLLDVDA GPSTNRTVYT FVGQPECVVE 60
GALSAARTAS QLIDMRKHKG EHPRMGALDV CPFIPVRGVS MDECVLCAKA FGQRLAEELN 120
VPVYLYGEAA QMPSRQTLPA IRAGEYEALP EKLKQAEWVP DFGPSSFVPS WGATVTGARK 180
FLIAFNINLL STKEQAHRIA LNLREQGRGK DQPGRLKKVQ GIGWYLEEKN LAQVSTNLLD 240
FEVTALHTVY EEARREAQEL NLPVVGSQLV GLVPLKALLD AAAFYCDKEK LFVLEEEHRI 300
RLVVNRLGLD SLAPFDPKER IIEYLVPDSG PEQSLLDASL RAFVREVGAR SAAPGGGSVA 360
AAVAALGAAL ASMVGQMTYG RRQFDHLDST MRRLIPPFHA ASAQLTSLVD ADARAFAACL 420
GAIKLPKNTP EERDRRTCAL QEGLRQAVAV PLKLAETVSQ LWPALQELAQ CGNLSCLSDL 480
QVAAKALETG VFGAYFNVLI NLKDMTDDVF KEKTRHRISS LLQEAKTQAA LVLGSLEARK 540
E 541 |
Gene Ontology | GO:0005814; C:centriole; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; IDA:RGD. GO:0005542; F:folic acid binding; IEA:UniProtKB-KW. GO:0030412; F:formimidoyltetrahydrofolate cyclodeaminase activity; TAS:RGD. GO:0030409; F:glutamate formimidoyltransferase activity; TAS:RGD. GO:0019215; F:intermediate filament binding; TAS:RGD. GO:0007010; P:cytoskeleton organization; IMP:RGD. GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway. GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway. GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |