CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001507
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SOGA1 
Protein Synonyms/Alias
 SOGA family member 1; Suppressor of glucose by autophagy; Suppressor of glucose, autophagy-associated protein 1; N-terminal form; C-terminal 80 kDa form; 80-kDa SOGA fragment 
Gene Name
 SOGA1 
Gene Synonyms/Alias
 C20orf117; KIAA0889; SOGA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
759LGSQGLSKEILLAKDubiquitination[1]
765SKEILLAKDLGSDFQubiquitination[1]
798RTGDLDSKPDPSRSFubiquitination[1]
889LQRRLEQKFWSQEKNubiquitination[2]
1011ELQQQFAKAKATWETubiquitination[1]
1047ERAGPDWKAALQRERubiquitination[3]
1086ERNWSQEKLQLVERLubiquitination[4]
1105QQVEQQVKELQNRLSubiquitination[3]
1116NRLSQLQKAADPWVLubiquitination[1, 3, 4]
1124AADPWVLKHSELEKQubiquitination[1, 3, 4]
1247RSYTAPDKTGIRVYYubiquitination[1, 4]
1286GFLFTTAKPKESAEAubiquitination[1, 4]
1288LFTTAKPKESAEADGubiquitination[4]
1366GSLERKVKSTSSQTVubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner (By similarity). 
Sequence Annotation
 MOD_RES 931 931 Phosphoserine.
 MOD_RES 1017 1017 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Secreted. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1423 AA 
Protein Sequence
MEAPAAEPPV RGCGPQPAPA PAPAPERKKS HRAPSPARPK DVAGWSLAKG RRGPGPGSAV 60
ACSAAFSSRP DKKGRAVAPG ARGAGVRVAG VRTGVRAKGR PRSGAGPRPP PPPPSLTDSS 120
SEVSDCASEE ARLLGLELAL SSDAESAAGG PAGVRTGQPA QPAPSAQQPP RPPASPDEPS 180
VAASSVGSSR LPLSASLAFS DLTEEMLDCG PSGLVRELEE LRSENDYLKD EIEELRAEML 240
EMRDVYMEED VYQLQELRQQ LDQASKTCRI LQYRLRKAER RSLRAAQTGQ VDGELIRGLE 300
QDVKVSKDIS MRLHKELEVV EKKRARLEEE NEELRQRLIE TELAKQVLQT ELERPREHSL 360
KKRGTRSLGK ADKKTLVQED SADLKCQLHF AKEESALMCK KLTKLAKEND SMKEELLKYR 420
SLYGDLDSAL SAEELADAPH SRETELKVHL KLVEEEANLL SRRIVELEVE NRGLRAEMDD 480
MKDHGGGCGG PEARLAFSAL GGGECGESLA ELRRHLQFVE EEAELLRRSS AELEDQNKLL 540
LNELAKFRSE HELDVALSED SCSVLSEPSQ EELAAAKLQI GELSGKVKKL QYENRVLLSN 600
LQRCDLASCQ STRPMLETDA EAGDSAQCVP APLGETHESH AVRLCRAREA EVLPGLREQA 660
ALVSKAIDVL VADANGFTAG LRLCLDNECA DFRLHEAPDN SEGPRDTKLI HAILVRLSVL 720
QQELNAFTRK ADAVLGCSVK EQQESFSSLP PLGSQGLSKE ILLAKDLGSD FQPPDFRDLP 780
EWEPRIREAF RTGDLDSKPD PSRSFRPYRA EDNDSYASEI KELQLVLAEA HDSLRGLQEQ 840
LSQERQLRKE EADNFNQKMV QLKEDQQRAL LRREFELQSL SLQRRLEQKF WSQEKNMLVQ 900
ESQQFKHNFL LLFMKLRWFL KRWRQGKVLP SEGDDFLEVN SMKELYLLME EEEINAQHSD 960
NKACTGDSWT QNTPNEYIKT LADMKVTLKE LCWLLRDERR GLTELQQQFA KAKATWETER 1020
AELKGHTSQM ELKTGKGAGE RAGPDWKAAL QREREEQQHL LAESYSAVME LTRQLQISER 1080
NWSQEKLQLV ERLQGEKQQV EQQVKELQNR LSQLQKAADP WVLKHSELEK QDNSWKETRS 1140
EKIHDKEAVS EVELGGNGLK RTKSVSSMSE FESLLDCSPY LAGGDARGKK LPNNPAFGFV 1200
SSEPGDPEKD TKEKPGLSSR DCNHLGALAC QDPPGRQMQR SYTAPDKTGI RVYYSPPVAR 1260
RLGVPVVHDK EGKIIIEPGF LFTTAKPKES AEADGLAESS YGRWLCNFSR QRLDGGSAGS 1320
PSAAGPGFPA ALHDFEMSGN MSDDMKEITN CVRQAMRSGS LERKVKSTSS QTVGLASVGT 1380
QTIRTVSVGL QTDPPRSSLH GKAWSPRSSS LVSVRSKQIS SSLDKVHSRI ERPCCSPKYG 1440
SPKLQRRSVS KLDSSKDRSL WNLHQGKQNG SAWARSTTTR DSPVLRNIND GLSSLFSVVE 1500
HSGSTESVWK LGMSETRAKP EPPKYGIVQE FFRNVCGRAP SPTSSAGEEG TKKPEPLSPA 1560
SYHQPEGVAR ILNKKAAKLG SSEEVRLTML PQVGKDGVLR DGDGAVVLPN EDAVCDCSTQ 1620
SLTSCFARSS RSAIRHSPSK CRLHPSESSW GGEERALPPS E 1661 
Gene Ontology
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0010506; P:regulation of autophagy; ISS:UniProtKB. 
Interpro
 IPR021507; DUF3166. 
Pfam
 PF11365; DUF3166 
SMART
  
PROSITE
  
PRINTS