UniProt Accession

 AMRP_RAT; Q99068; Q4FZX8; Q642A1; Q64723 

Genbank Protein ID

 BC082020; BC098947; Z11994; Z11995; M31051 

Genbank Nucleotide ID

 AAH82020.1; AAH98947.1; CAA78040.1; CAA78041.1; AAA41269.1 

Protein Name

 Alpha-2-macroglobulin receptor-associated protein 

Protein Synonyms/Alias

 Alpha-2-MRAP; Gp330-binding 45 kDa protein; Low density lipoprotein receptor-related protein-associated protein 1; RAP 

Gene Name

 Lrpap1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
68	KLNQLWEKAKRLHLS	acetylation	[1]
97	ERDELNWKKLKVEGL	acetylation	[1]
100	ELNWKKLKVEGLDGD	acetylation	[1]
110	GLDGDGEKEAKLVHN	acetylation	[1]
156	LGDPRLEKLWHKAKT	acetylation	[1]
166	HKAKTSGKFSSEELD	acetylation	[1]
183	WREFLHYKEKIHEYN	acetylation	[1]
185	EFLHYKEKIHEYNVL	acetylation	[1]
228	ASKHSELKDRLRSIN	acetylation	[1]
285	ESFREELKHFEAKIE	acetylation	[1]
290	ELKHFEAKIEKHNHY	acetylation	[1]
299	EKHNHYQKQLEISHQ	acetylation	[1]
307	QLEISHQKLKHVESI	acetylation	[1]
309	EISHQKLKHVESIGD	acetylation	[1]
326	HISRNKEKYVLLEEK	acetylation	[1]
333	KYVLLEEKTKELGYK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. 

Sequence Annotation

 REGION 240 356 LDL receptor binding (Potential).
 MOTIF 357 360 Prevents secretion from ER (Potential).
 CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Heparin-binding; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0048237; C:rough endoplasmic reticulum lumen; IDA:RGD.
 GO:0031982; C:vesicle; IDA:RGD.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:1900116; P:extracellular negative regulation of signal transduction; IEA:Compara.
 GO:1900222; P:negative regulation of beta-amyloid clearance; IEA:Compara.
 GO:0032091; P:negative regulation of protein binding; IEA:Compara.
 GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Compara. 

Interpro

 IPR010483; Alpha_2_MRAP_C.
 IPR009066; MG_RAP_rcpt_1. 

Pfam

 PF06401; Alpha-2-MRAP_C
 PF06400; Alpha-2-MRAP_N 

SMART

  

PROSITE

 PS00014; ER_TARGET 

PRINTS