| Tag | Content |
|---|
| CPLM ID | CPLM-030884 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine--tRNA ligase, cytoplasmic |
Protein Synonyms/Alias | cDNA FLJ58533, highly similar to Leucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.4) |
Gene Name | LARS |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 28 | GYQRLKGKCCLFPFG | ubiquitination | [1] | | 44 | HCTGMPIKACADKLK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | |
Sequence Annotation | |
Keyword | Aminoacyl-tRNA synthetase; Complete proteome; Ligase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1122 AA |
Protein Sequence | MNGRLHLGHT FSLSKCEFAV GYQRLKGKCC LFPFGLHCTG MPIKACADKL KREIELYGCP 60
PDFPDEEEEE EETSVKTEDI IIKDKAKGKK SKAAAKAGSS KYQWGIMKSL GLSDEEIVKF 120
SEAEHWLDYF PPLAIQDLKR MGLKVDWRRS FITTDVNPYY DSFVRWQFLT LRERNKIKFG 180
KRYTIYSPKD GQPCMDHDRQ TGEGVGPQEY TLLKLKVLEP YPSKLSGLKG KNIFLVAATL 240
RPETMFGQTN CWVRPDMKYI GFETVNGDIF ICTQKAARNM SYQGFTKDNG VVPVVKELMG 300
EEILGASLSA PLTSYKVIYV LPMLTIKEDK GTGVVTSVPS DSPDDIAALR DLKKKQALRA 360
KYGIRDDMVL PFEPVPVIEI PGFGNLSAVT ICDELKIQSQ NDREKLAEAK EKIYLKGFYE 420
GIMLVDGFKG QKVQDVKKTI QKKMIDAGDA LIYMEPEKQV MSRSSDECVV ALCDQWYLDY 480
GEENWKKQTS QCLKNLETFC EETRRNFEAT LGWLQEHACS RTYGLGTHLP WDEQWLIESL 540
SDSTIYMAFY TVAHLLQGGN LHGQAESPLG IRPQQMTKEV WDYVFFKEAP FPKTQIAKEK 600
LDQLKQEFEF WYPVDLRVSG KDLVPNHLSY YLYNHVAMWP EQSDKWPTAV RANGHLLLNS 660
EKMSKSTGNF LTLTQAIDKF SADGMRLALA DAGDTVEDAN FVEAMADAGI LRLYTWVEWV 720
KEMVANWDSL RSGPASTFND RVFASELNAG IIKTDQNYEK MMFKEALKTG FFEFQAAKDK 780
YRELAVEGMH RELVFRFIEV QTLLLAPFCP HLCEHIWTLL GKPDSIMNAS WPVAGPVNEV 840
LIHSSQYLME VTHDLRLRLK NYMMPAKGKK TDKQPLQKPS HCTIYVAKNY PPWQHTTLSV 900
LRKHFEANNG KLPDNKVIAS ELGSMPELKK YMKKVMPFVA MIKENLEKMG PRILDLQLEF 960
DEKAVLMENI VYLTNSLELE HIEVKFASEA EDKIREDCCP GKPLNVFRIE PGVSVSLVNP 1020
QPSNGHFSTK IEIRQGDNCD SIIRRLMKMN RGIKDLSKVK LMRFDDPLLG PRRVPVLGKE 1080
YTEKTPISEH AVFNVDLMSK KIHLTENGIR VDIGDTIIYL VH 1122 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro. GO:0005524; F:ATP binding; IEA:InterPro. GO:0004823; F:leucine-tRNA ligase activity; IEA:InterPro. GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro. GO:0006450; P:regulation of translational fidelity; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |