CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020284
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 416 
Protein Synonyms/Alias
  
Gene Name
 ZNF416 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
366CGKAFGSKSTLVRHQubiquitination[1, 2]
480KAFMFKSKLVRHQRTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 28 111 KRAB.
 ZN_FING 242 264 C2H2-type 1; degenerate.
 ZN_FING 270 292 C2H2-type 2.
 ZN_FING 298 320 C2H2-type 3.
 ZN_FING 326 348 C2H2-type 4.
 ZN_FING 354 376 C2H2-type 5.
 ZN_FING 382 404 C2H2-type 6.
 ZN_FING 410 432 C2H2-type 7.
 ZN_FING 438 460 C2H2-type 8.
 ZN_FING 466 488 C2H2-type 9.
 ZN_FING 494 516 C2H2-type 10.
 ZN_FING 522 544 C2H2-type 11.
 ZN_FING 550 572 C2H2-type 12.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 594 AA 
Protein Sequence
MAAAVLRDST SVPVTAEAKL MGFTQGCVTF EDVAIYFSQE EWGLLDEAQR LLYRDVMLEN 60
FALITALVCW HGMEDEETPE QSVSVEGVPQ VRTPEASPST QKIQSCDMCV PFLTDILHLT 120
DLPGQELYLT GACAVFHQDQ KHHSAEKPLE SDMDKASFVQ CCLFHESGMP FTSSEVGKDF 180
LAPLGILQPQ AIANYEKPNK ISKCEEAFHV GISHYKWSQC RRESSHKHTF FHPRVCTGKR 240
LYESSKCGKA CCCECSLVQL QRVHPGERPY ECSECGKSFS QTSHLNDHRR IHTGERPYVC 300
GQCGKSFSQR ATLIKHHRVH TGERPYECGE CGKSFSQSSN LIEHCRIHTG ERPYECDECG 360
KAFGSKSTLV RHQRTHTGEK PYECGECGKL FRQSFSLVVH QRIHTTARPY ECGQCGKSFS 420
LKCGLIQHQL IHSGARPFEC DECGKSFSQR TTLNKHHKVH TAERPYVCGE CGKAFMFKSK 480
LVRHQRTHTG ERPFECSECG KFFRQSYTLV EHQKIHTGLR PYDCGQCGKS FIQKSSLIQH 540
QVVHTGERPY ECGKCGKSFT QHSGLILHRK SHTVERPRDS SKCGKPYSPR SNIV 594 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS