UniProt Accession

 D3YVX6_MOUSE; D3YVX6 

Genbank Protein ID

 AC087061 

Genbank Nucleotide ID

  

Protein Name

 Sodium/potassium-transporting ATPase subunit alpha-2 

Protein Synonyms/Alias

  

Gene Name

 Atp1a2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
28	GKKKQKEKELDELKK	ubiquitination	[1]
34	EKELDELKKEVAMDD	ubiquitination	[1]
35	KELDELKKEVAMDDH	ubiquitination	[1]
43	EVAMDDHKLSLDELG	ubiquitination	[1]
52	SLDELGRKYQVDLSK	ubiquitination	[1]
59	KYQVDLSKGLTNQRA	ubiquitination	[1]
154	YQEAKSSKIMDSFKN	ubiquitination	[1]
160	SKIMDSFKNMVPQQA	ubiquitination	[1]
175	LVIREGEKMQINAEE	ubiquitination	[1]
192	VGDLVEVKGGDRVPA	ubiquitination	[1]
210	IISSHGCKVDNSSLT	ubiquitination	[1]
352	TAKRMARKNCLVKNL	ubiquitination	[1]
357	ARKNCLVKNLEAVET	ubiquitination	[1]
375	TSTICSDKTGTLTQN	ubiquitination	[1]
411	QSGATFDKRSPTWTA	ubiquitination	[1]
432	LCNRAVFKAGQENIS	ubiquitination	[1]
442	QENISVSKRDTAGDA	ubiquitination	[1]
474	KMRDRNPKVAEIPFN	ubiquitination	[1]
505	QSHVLVMKGAPERIL	ubiquitination	[1]
523	STILVQGKEIPLDKE	ubiquitination	[1]
529	GKEIPLDKEMQDAFQ	ubiquitination	[1]
561	QLNLPSGKFPRGFKF	ubiquitination	[1]
567	GKFPRGFKFDTDELN	ubiquitination	[1]
602	AVPDAVGKCRSAGIK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Hydrolase; Membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 673 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0015077; F:monovalent inorganic cation transmembrane transporter activity; IEA:InterPro.
 GO:0008344; P:adult locomotory behavior; IMP:MGI.
 GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
 GO:0040011; P:locomotion; IMP:MGI.
 GO:0045822; P:negative regulation of heart contraction; IMP:MGI.
 GO:0045988; P:negative regulation of striated muscle contraction; IMP:MGI.
 GO:0001504; P:neurotransmitter uptake; IMP:MGI.
 GO:0051481; P:reduction of cytosolic calcium ion concentration; IMP:MGI.
 GO:0008217; P:regulation of blood pressure; IGI:MGI.
 GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IMP:MGI.
 GO:0006940; P:regulation of smooth muscle contraction; IMP:MGI.
 GO:0002026; P:regulation of the force of heart contraction; IMP:MGI.
 GO:0019229; P:regulation of vasoconstriction; IMP:MGI.
 GO:0008542; P:visual learning; IMP:MGI. 

Interpro

 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR005775; ATPase_P-typ_Na/K_IIC.
 IPR018303; ATPase_P-typ_P_site.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 

Pfam

 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase 

SMART

 SM00831; Cation_ATPase_N 

PROSITE

 PS00154; ATPASE_E1_E2 

PRINTS

 PR00119; CATATPASE.