CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001190
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor Maf 
Protein Synonyms/Alias
 Proto-oncogene c-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog 
Gene Name
 MAF 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29VNDFDLMKFEVKKEPsumoylation[1]
33DLMKFEVKKEPVETDsumoylation[1, 2]
331LQQVDHLKQEISRLVsumoylation[1]
Reference
 [1] SUMOylation attenuates c-Maf-dependent IL-4 expression.
 Lin BS, Tsai PY, Hsieh WY, Tsao HW, Liu MW, Grenningloh R, Wang LF, Ho IC, Miaw SC.
 Eur J Immunol. 2010 Apr;40(4):1174-84. [PMID: 20127678]
 [2] SUMOylation negatively regulates transcriptional and oncogenic activities of MafA.
 Kanai K, Reza HM, Kamitani A, Hamazaki Y, Han SI, Yasuda K, Kataoka K.
 Genes Cells. 2010 Sep 1;15(9):971-82. [PMID: 20718938] 
Functional Description
 Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)- mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. 
Sequence Annotation
 DOMAIN 288 351 bZIP.
 REGION 126 373 Represses ARE-mediated transcription.
 REGION 288 313 Basic motif (By similarity).
 REGION 316 337 Leucine-zipper (By similarity).  
Keyword
 Activator; Alternative splicing; Cataract; Chromosomal rearrangement; Complete proteome; Disease mutation; DNA-binding; Nucleus; Proto-oncogene; Reference proteome; Repressor; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 373 AA 
Protein Sequence
MASELAMSNS DLPTSPLAME YVNDFDLMKF EVKKEPVETD RIISQCGRLI AGGSLSSTPM 60
STPCSSVPPS PSFSAPSPGS GSEQKAHLED YYWMTGYPQQ LNPEALGFSP EDAVEALISN 120
SHQLQGGFDG YARGAQQLAA AAGAGAGASL GGSGEEMGPA AAVVSAVIAA AAAQSGAGPH 180
YHHHHHHAAG HHHHPTAGAP GAAGSAAASA GGAGGAGGGG PASAGGGGGG GGGGGGGGAA 240
GAGGALHPHH AAGGLHFDDR FSDEQLVTMS VRELNRQLRG VSKEEVIRLK QKRRTLKNRG 300
YAQSCRFKRV QQRHVLESEK NQLLQQVDHL KQEISRLVRE RDAYKEKYEK LVSSGFRENG 360
SSSDNPSSPE FFM 373 
Gene Ontology
 GO:0000785; C:chromatin; TAS:ProtInc.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0048468; P:cell development; IEA:Compara.
 GO:0001816; P:cytokine production; IEA:Compara.
 GO:0048839; P:inner ear development; IEA:Compara.
 GO:0070306; P:lens fiber cell differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0032330; P:regulation of chondrocyte differentiation; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 
Interpro
 IPR004827; bZIP.
 IPR004826; bZIP_Maf.
 IPR008917; Euk_TF_DNA-bd.
 IPR013592; Maf_TF_N.
 IPR024874; Transciption_factor_Maf. 
Pfam
 PF03131; bZIP_Maf
 PF08383; Maf_N 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS