CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009627
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 F-box only protein 40 
Protein Synonyms/Alias
  
Gene Name
 Fbxo40 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
306LKTAVDAKDYNMYLVubiquitination[1]
352VKTVYTFKIPVSYCGubiquitination[1]
360IPVSYCGKRARLGDAubiquitination[1]
692SMCQPQEKARESLVSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis. 
Sequence Annotation
 DOMAIN 572 626 F-box.
 ZN_FING 53 114 TRAF-type.  
Keyword
 Complete proteome; Cytoplasm; Metal-binding; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 710 AA 
Protein Sequence
MGRARKPPPA LHRHCEGCFN RHCHVPVEPS VSCLVISCHL LCGATFHMCK ESEHTLLCPL 60
EQVPCLNSEY GCPLSMARHK LAKHLQVCPA SVVCCSMEWI RWPNVDSETF LHENIMKETP 120
SEECLDTALA LQDQKVLFRS LKMVELFPET RDATEEEPDM NGDTSWEETG GAVGGVDARL 180
APNSCLPATS RQMMELSQEE RDALAKTKEG MDLDKFGKWE SMFSKEHAAS VLTGSLGKSE 240
DKNGDVAGKE QCSSNVRIGD AEGSAERRGP QESQKSQELP ATMEMTGLAP WQDGVLERLK 300
TAVDAKDYNM YLVHNGRMLI HFGQMPACTP KERDFVYGNL EAQEVKTVYT FKIPVSYCGK 360
RARLGDAMLK CRPSEHKAVD TSDLGISVED LPKSDLIKTT LQCALERELK GHVISESRSI 420
DGLFMDLATQ TYNFEPEQFS SETVLADLLG TAQPGGLHVE LHSECVTRRH NKSSSAFTFT 480
CNKFFRRDEF PLHFKNVHTD IQSSLDGWFQ HRCPLAYLGC TFVQNHFRPP GQKAKVIYSQ 540
ELKTFAIKPE VAPELSEKWK SDHLSGRDGK SLNSLTSLPL EVLQYIAGFL DSISLSQLSQ 600
VSVLMRNICA TLLQERGMVL SQWKKKRYSH GGTSWKVHNQ IWQFSSLFSK INSWEFNDVT 660
SMSEHLKTCP FNIVERKTDP IRLTSMCQPQ EKARESLVST FRARPRGRHF 710 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042692; P:muscle cell differentiation; IEP:UniProtKB. 
Interpro
 IPR001810; F-box_dom_cyclin-like.
 IPR013323; SIAH-type.
 IPR001293; Znf_TRAF. 
Pfam
  
SMART
  
PROSITE
 PS50181; FBOX
 PS50145; ZF_TRAF 
PRINTS