UniProt Accession

 CNTRB_HUMAN; Q8N137; A6NHQ1; Q331K3; Q69YV7; Q8NCB8; Q8WXV3; Q96CQ7; Q9C060 

Genbank Protein ID

 AY160226; AY160227; AF331638; AL137669; AL833907; AC104581; BC014055; BC021134; AK074847; AF141344 

Genbank Nucleotide ID

 AAO22135.1; AAO22136.1; AAL56068.2; CAH10698.1; CAD38763.1; AAH14055.3; AAH21134.1; BAC11241.1; AAG49447.1 

Protein Name

 Centrobin 

Protein Synonyms/Alias

 Centrosomal BRCA2-interacting protein; LYST-interacting protein 8 

Gene Name

 CNTROB 

Gene Synonyms/Alias

 LIP8; PP1221 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
610	PPMAVALKPVLQQSR	ubiquitination	[1, 2, 3]
698	PDGEGLLKQGLPPAQ	ubiquitination	[2, 4]
832	EDLLLYLKRLEHSGT	ubiquitination	[4, 5]
861	RLGEIPRKEIPSQAV	ubiquitination	[2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. 

Sequence Annotation

 REGION 365 903 Required for centrosome localization.  

Keyword

 Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 903 AA 

Protein Sequence

Gene Ontology

 GO:0005814; C:centriole; IDA:HGNC.
 GO:0007099; P:centriole replication; IMP:HGNC.
 GO:0051299; P:centrosome separation; IMP:HGNC.
 GO:0000910; P:cytokinesis; IMP:HGNC. 

Interpro

  

Pfam

  

SMART

  

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PRINTS