CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016125
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 28S ribosomal protein S26, mitochondrial 
Protein Synonyms/Alias
 MRP-S26; S26mt 
Gene Name
 Mrps26 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
159LKEQEVLKLQEEAKNacetylation[1, 2, 3, 4, 5, 6]
159LKEQEVLKLQEEAKNsuccinylation[5]
165LKLQEEAKNFITRENacetylation[2]
193SYNWAVTKEGQVVRNacetylation[4]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 200 AA 
Protein Sequence
MLRALNRLAA RPETRPPTPL LLPVRGRKTR HDPPAKSKVG RVQTPPAVDP AEFFVLTERY 60
RQYRETVRAL RLEFTLEVRR KLHEARAGVL AERKAQQAIT EHRELMAWNR DENRRMQELR 120
IARLQLEAQA QEVQKAEAQA QRAQEEQAWV QLKEQEVLKL QEEAKNFITR ENLEARIEEA 180
LDSPKSYNWA VTKEGQVVRN 200 
Gene Ontology
 GO:0005763; C:mitochondrial small ribosomal subunit; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:MGI. 
Interpro
 IPR026140; MRPS26. 
Pfam
  
SMART
  
PROSITE
  
PRINTS