UniProt Accession

 UPPS_SALTY; Q8ZRP2 

Genbank Protein ID

 AE006468 

Genbank Nucleotide ID

 AAL19185.1 

Protein Name

 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) 

Protein Synonyms/Alias

 Ditrans,polycis-undecaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS; Undecaprenyl pyrophosphate synthase; UPP synthase 

Gene Name

 uppS 

Gene Synonyms/Alias

 STM0221 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
36	RWAKKQGKIRAFGHK	acetylation	[1]
43	KIRAFGHKAGAKSVR	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide (By similarity). 

Sequence Annotation

 REGION 26 29 Substrate binding (By similarity).
 REGION 70 72 Substrate binding (By similarity).
 REGION 199 201 Substrate binding (By similarity).
 ACT_SITE 25 25 By similarity.
 ACT_SITE 73 73 Proton acceptor (By similarity).
 METAL 25 25 Magnesium (By similarity).
 METAL 198 198 Magnesium (By similarity).
 METAL 212 212 Magnesium (By similarity).
 BINDING 30 30 Substrate (By similarity).
 BINDING 38 38 Substrate (By similarity).
 BINDING 42 42 Substrate (By similarity).
 BINDING 74 74 Substrate (By similarity).
 BINDING 76 76 Substrate (By similarity).
 BINDING 193 193 Substrate (By similarity).  

Keyword

 Cell shape; Cell wall biogenesis/degradation; Complete proteome; Magnesium; Metal-binding; Peptidoglycan synthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0008834; F:di-trans,poly-cis-decaprenylcistransferase activity; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. 

Interpro

 IPR001441; UPP_synth-like.
 IPR018520; UPP_synth-like_CS. 

Pfam

 PF01255; Prenyltransf 

SMART

  

PROSITE

 PS01066; UPP_SYNTHASE 

PRINTS