| Tag | Content |
|---|
| CPLM ID | CPLM-023380 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Polycomb protein Scm |
Protein Synonyms/Alias | Sex comb on midleg protein |
Gene Name | Scm |
Gene Synonyms/Alias | CG9495 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 210 | NDFKIGMKLEALDPR | sumoylation | [1] | | 574 | SPSEKIIKQELAVKS | sumoylation | [1] | | 624 | SSNKVVIKSEPNGAN | sumoylation | [1] |
|
Reference | [1] Small ubiquitin-like modifier (SUMO) conjugation impedes transcriptional silencing by the polycomb group repressor Sex Comb on Midleg. Smith M, Mallin DR, Simon JA, Courey AJ. J Biol Chem. 2011 Apr 1;286(13):11391-400. [ PMID: 21278366] |
Functional Description | Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. |
Sequence Annotation | REPEAT 175 273 MBT 1.
REPEAT 281 382 MBT 2.
DOMAIN 806 876 SAM.
ZN_FING 54 93 FCS-type.
MOD_RES 546 546 Phosphothreonine.
MOD_RES 549 549 Phosphoserine.
MOD_RES 550 550 Phosphoserine.
MOD_RES 585 585 Phosphoserine. |
Keyword | 3D-structure; Chromatin regulator; Complete proteome; Developmental protein; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 877 AA |
Protein Sequence | MSGGRDSSTS SGSNSAAPGA STNATSSASA SASSTSTSAS PGSTTSPAST QRQRGRPAKR 60
ATCTWCGEGK LPLQYVLPTQ TGKKEFCSET CIAEFRKAYS KGACTQCDNV IRDGAPNKEF 120
CSIMCMNKHQ KKNCSTRHSG GSASGKGLAE SERKLLASGA PAPTGPFQYE SFHVFDWDAY 180
LEETGSEAAP AKCFKQAQNP PNNDFKIGMK LEALDPRNVT STCIATVVGV LGSRLRLRLD 240
GSDSQNDFWR LVDSTEIHAI GHCEKNGGML QPPLGFRMNA SSWPGYLCKI LNNAMVAPEE 300
IFQPEPPEPE ENLFKVGQKL EAVDKKNPQL ICCATVDAIK DDQIHVTFDG WRGAFDYWCN 360
YRSRDIFPAG WCARSCHPMQ PPGHKSRMDS SSSKQRCPRP RYTVVAESEA MVPASPATAH 420
FHPNCKGGPF INNSKLPCMV TGPTYQTLAK LCLQEVLAAS TDTQQLSKLL FALEGDVHIV 480
TAAGKNFTVK IPSPMRMKDD ESLAQFIETL CTTCRACANL ISLVHETEEC KKCANSRKRQ 540
LTQSATPPSS PVLADKRNRQ SNSATTSPSE KIIKQELAVK SPVESKSKTS TNNGKEPASQ 600
QNSNHSLNNN NNSASKSSNK VVIKSEPNGA NAQTSSTTQA LRKVRFQHHA NTNTNSSATN 660
GNQDTSQTTH VSTSHCSSSS TSSSTSLAGG SANTSTIGKY LAPLVAEVHP EQANVKPSNS 720
YYKSPTTLSS SASLPTSVST PFTGCQSASS TALAAGGVTA AKAATAPAGA AATAGASPSY 780
TAITSPVSTP TSALANSHLR SQPIDWTIEE VIQYIESNDN SLAVHGDLFR KHEIDGKALL 840
LLNSEMMMKY MGLKLGPALK ICNLVNKVNG RRNNLAL 877 |
Gene Ontology | GO:0035102; C:PRC1 complex; TAS:FlyBase. GO:0008270; F:zinc ion binding; NAS:UniProtKB. GO:0007409; P:axonogenesis; IMP:FlyBase. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0016458; P:gene silencing; IMP:UniProtKB. GO:0030708; P:germarium-derived female germ-line cyst encapsulation; IMP:FlyBase. GO:0045892; P:negative regulation of transcription, DNA-dependent; TAS:UniProtKB. GO:0030713; P:ovarian follicle cell stalk formation; IMP:FlyBase. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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