CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019976
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Carbohydrate-responsive element-binding protein 
Protein Synonyms/Alias
 ChREBP; MLX interactor; MLX-interacting protein-like; Williams-Beuren syndrome chromosomal region 14 protein homolog 
Gene Name
 Mlxipl 
Gene Synonyms/Alias
 Mio; Wbscr14 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
113WKNFKGLKLLCRDKIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. 
Sequence Annotation
 DOMAIN 661 715 bHLH.
 REGION 715 736 Leucine-zipper.
 MOD_RES 23 23 Phosphoserine.
 MOD_RES 25 25 Phosphoserine.
 MOD_RES 517 517 Phosphothreonine.
 MOD_RES 566 566 Phosphoserine; by AMPK (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 864 AA 
Protein Sequence
MARALADLSV NLQVPRVVPS PDSDSDTDLE DPSPRRSAGG LHRSQVIHSG HFMVSSPHSD 60
SLTRRRDQEG PVGLADFGPR SIDPTLTHLF ECLSLAYSGK LVSPKWKNFK GLKLLCRDKI 120
RLNNAIWRAW YIQYVQRRKS PVCGFVTPLQ GSEADEHRKP EAVILEGNYW KRRIEVVMRE 180
YHKWRIYYKK RLRKSSREGD FLAPKQVEGG WPPPERWCEQ LFSSVVPVLL GGSEEEPGGR 240
QLLDLDCFLS DISDTLFTMT QPSPSSLQLP PEDAYVGNAD MIQPDLTPLQ PSLDDFMEIS 300
DFFTNYRPPQ TPTSSNYIES PSFGPMADSL FSSGILAPEM PSPASSSSSS GMTPHSGNTR 360
LQARNSCSGP LDPNPFLSSE FLLPEDPKTK IPPAPGPTPL LPFPTPVKVH GLEPCTPSPF 420
PTMAPPPSLL PEESLLSARF PFTSAPPAPG VSTLPAPTTF VPTPQPGPGP VPFSVDHLPH 480
GYLEPVFGPH FTVPQGMQPR CKPSSPSPGG QKASPPTLAS ATASPTATAT ARDNNPCLTQ 540
LLRAAKPEQA LEPPTMPGTL LRPPESPQDT VSEIPRARAF FPPIPAPTPP RPPPGPATLA 600
PPRSLVVPKA ERLSPPASSG SERRLSGDLN SIQPSGALSV HLSPPQTVLS RGRVDNNKME 660
NRRITHISAE QKRRFNIKLG FDTLHGLVST LSAQPSLKVS KATTLQKTAE YILMLQQERA 720
AMQEEAQQLR DEIEELNAAI NLCQQQLPAT GVPITHQRFD QMRDMFDDYV RTRTLHNWKF 780
WVFSILIRPL FESFNGMVST ASLHSLRQTS LAWLEQYCSL PALRPTVLNS LRQLSTSTSI 840
LTDPSLVPEQ ATRAVTEGTL GRPL 864 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0035538; F:carbohydrate response element binding; TAS:BHF-UCL.
 GO:0008134; F:transcription factor binding; IDA:BHF-UCL.
 GO:0055089; P:fatty acid homeostasis; ISS:UniProtKB.
 GO:0010255; P:glucose mediated signaling pathway; IDA:BHF-UCL.
 GO:0071157; P:negative regulation of cell cycle arrest; IEA:Compara.
 GO:0090324; P:negative regulation of oxidative phosphorylation; IEA:Compara.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0045723; P:positive regulation of fatty acid biosynthetic process; IMP:BHF-UCL.
 GO:0045821; P:positive regulation of glycolysis; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:2000505; P:regulation of energy homeostasis; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011598; bHLH_dom. 
Pfam
 PF00010; HLH 
SMART
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS