| Tag | Content |
|---|
| CPLM ID | CPLM-015873 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nucleus accumbens-associated protein 1 |
Protein Synonyms/Alias | NAC-1; BTB/POZ domain-containing protein 14B |
Gene Name | Nacc1 |
Gene Synonyms/Alias | Btbd14b; Nac1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 466 | KSWLPKTKPLHLVEG | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Involved in the acute behavioral and neurological responses to cocaine and amphetamines. |
Sequence Annotation | DOMAIN 30 94 BTB.
DOMAIN 360 457 BEN.
MOD_RES 187 187 Phosphoserine (By similarity).
MOD_RES 245 245 Phosphoserine; by PKC (By similarity). |
Keyword | Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 514 AA |
Protein Sequence | MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN 60
SSRSAVVELP AAVQPQSFQQ ILTFCYTGRL SMNMGDQFLL IYTAGFLQIQ EIMEKGTEFF 120
LKVSSPSCDS QGLHPEEAPS SEPQSPVAQT LGWPACSTPL PLVSRVKTEQ ELDSVQCTPM 180
AKRLWDSSQK EAGGSGGNNG SRKMAKFSTP DLALNRMPQP LSMATATAAV AVVAVGGCVS 240
GPSMSERTSP GTSSAYTSDS PSSYHNEEDE EEDAGEEGTD EQYRQICNMY TMYSMLNVGQ 300
TAEKVEALPE QVVLESRSRI RVRQDLASLP AELINQIGNR CHPKLYDEGD PSEKLELVTG 360
TNVYITRAQL MNCHVSAGTR HKVLLRRLLA SFFDRNTLAN SCGTGIRSST NDPRRKPLDS 420
RVLHAVKYYC QNFAPNFKES EMNAIAADMC TNARRVVRKS WLPKTKPLHL VEGDNYSSFI 480
SDTCKIEPDM MSMEHSFETA SHDGEAGPSA EVLQ 514 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016604; C:nuclear body; ISS:UniProtKB. GO:0006917; P:induction of apoptosis; IEA:Compara. GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB. GO:0051260; P:protein homooligomerization; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |