CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037941
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase Sgk1 
Protein Synonyms/Alias
  
Gene Name
 SGK1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
9TVKTEAAKGTLTYSRubiquitination[1]
111IGKGSFGKVLLARHKubiquitination[2]
127EEVFYAVKVLQKKAIubiquitination[1]
227LAPEVLHKQPYDRTVubiquitination[1]
268MYDNILNKPLQLKPNubiquitination[1]
273LNKPLQLKPNITNSAubiquitination[1]
356PVPNSIGKSPDSVLVubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 387 AA 
Protein Sequence
MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HPEVQSILKI 60
SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE 120
EVFYAVKVLQ KKAILKKKEL FYHLQRERCF LEPRARFYAA EIASALGYLH SLNIVYRDLK 180
PENILLDSQG HIVLTDFGLC KENIEHNSTT STFCGTPEYL APEVLHKQPY DRTVDWWCLG 240
AVLYEMLYGL PPFYSRNTAE MYDNILNKPL QLKPNITNSA RHLLEGLLQK DRTKRLGAKD 300
DFMEIKSHVF FSLINWDDLI NKKITPPFNP NVSGPNDLRH FDPEFTEEPV PNSIGKSPDS 360
VLVTASVKEA AEAFLGFSYA PPTDSFL 387 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS