CPLM-001545

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-001545

UniProt Accession

RTN3_HUMAN; O95197; B3KQS2; B7Z308; B7Z4M0; F5H774; Q147U9; Q496K2; Q53GN3; Q59EP0; Q5UEP2; Q6T930; Q7RTM7; Q7RTM8; Q7RTN3

Genbank Protein ID

AF059524; AF059529; AF059525; AF059526; AF059527; AF059528; AF119297; AY427821; AY750848; AP000753; AP006289; AK297529; AB209771; AK075412; AK222898; AK295361; CH471076; BC000634; BC010556; BC011394; BC022993; BC100822; BC100823; BC105981; BC105982; BC118628; BC118550; BK001685; BK001681; BK001684

Genbank Nucleotide ID

AAC99319.1; AAD20951.1; AAD20951.1; AAD20951.1; AAD20951.1; AAD20951.1; AAD26810.1; AAR02474.1; AAU81930.1; BAH12606.1; BAD93008.1; BAG52134.1; BAD96618.1; BAH12044.1; EAW74170.1; AAH00634.1; AAH10556.1; AAH11394.1; AAH22993.1; AAI00823.1; AAI00824.1; AAI05982.1; AAI05983.1; AAI18629.1; AAI18551.1; DAA01931.1; DAA01941.1; DAA01943.1

Protein Name

Reticulon-3

Protein Synonyms/Alias

Homolog of ASY protein; HAP; Neuroendocrine-specific protein-like 2; NSP-like protein 2; Neuroendocrine-specific protein-like II; NSP-like protein II; NSPLII

Gene Name

RTN3

Gene Synonyms/Alias

ASYIP; NSPL2

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
979	PIVYEKYKTQIDHYV	ubiquitination	[1]
994	GIARDQTKSIVEKIQ	ubiquitination	[1]
999	QTKSIVEKIQAKLPG	ubiquitination	[1]
1003	IVEKIQAKLPGIAKK	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis.

Sequence Annotation

DOMAIN 844 1032 Reticulon.
REGION 987 1032 Interaction with FADD.
REGION 1000 1002 Interaction with BACE1.
MOD_RES 2 2 N-acetylalanine.
MOD_RES 243 243 Phosphoserine (By similarity).
MOD_RES 649 649 Phosphoserine.
MOD_RES 650 650 Phosphoserine.
MOD_RES 735 735 Phosphoserine (By similarity).

Keyword

Acetylation; Alternative splicing; Apoptosis; Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Host-virus interaction; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Stress response; Transmembrane; Transmembrane helix; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1032 AA

Protein Sequence

MAEPSAATQS HSISSSSFGA EPSAPGGGGS PGACPALGTK SCSSSCAEGL SSLCSDEPSS 60
EIMTSSFLSS SEIHNTGLTI LHGEKSHVLG SQPILAKEGK DHLDLLDMKK MEKPQGTSNN 120
VSDSSVSLAA GVHCDRPSIP ASFPEHPAFL SKKIGQVEEQ IDKETKNPNG VSSREAKTAL 180
DADDRFTLLT AQKPPTEYSK VEGIYTYSLS PSKVSGDDVI EKDSPESPFE VIIDKAAFDK 240
EFKDSYKEST DDFGSWSVHT DKESSEDISE TNDKLFPLRN KEAGRYPMSA LLSRQFSHTN 300
AALEEVSRCV NDMHNFTNEI LTWDLVPQVK QQTDKSSDCI TKTTGLDMSE YNSEIPVVNL 360
KTSTHQKTPV CSIDGSTPIT KSTGDWAEAS LQQENAITGK PVPDSLNSTK EFSIKGVQGN 420
MQKQDDTLAE LPGSPPEKCD SLGSGVATVK VVLPDDHLKD EMDWQSSALG EITEADSSGE 480
SDDTVIEDIT ADTSFENNKI QAEKPVSIPS AVVKTGEREI KEIPSCEREE KTSKNFEELV 540
SDSELHQDQP DILGRSPASE AACSKVPDTN VSLEDVSEVA PEKPITTENP KLPSTVSPNV 600
FNETEFSLNV TTSAYLESLH GKNVKHIDDS SPEDLIAAFT ETRDKGIVDS ERNAFKAISE 660
KMTDFKTTPP VEVLHENESG GSEIKDIGSK YSEQSKETNG SEPLGVFPTQ GTPVASLDLE 720
QEQLTIKALK ELGERQVEKS TSAQRDAELP SEEVLKQTFT FAPESWPQRS YDILERNVKN 780
GSDLGISQKP ITIRETTRVD AVSSLSKTEL VKKHVLARLL TDFSVHDLIF WRDVKKTGFV 840
FGTTLIMLLS LAAFSVISVV SYLILALLSV TISFRIYKSV IQAVQKSEEG HPFKAYLDVD 900
ITLSSEAFHN YMNAAMVHIN RALKLIIRLF LVEDLVDSLK LAVFMWLMTY VGAVFNGITL 960
LILAELLIFS VPIVYEKYKT QIDHYVGIAR DQTKSIVEKI QAKLPGIAKK KAE 1013

Gene Ontology

GO:0005783; C:endoplasmic reticulum; IDA:HPA.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005615; C:extracellular space; TAS:ProtInc.
GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0071786; P:endoplasmic reticulum tubular network organization; IMP:UniProtKB.
GO:0006950; P:response to stress; IEA:UniProtKB-KW.
GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW.

Interpro

IPR003388; Reticulon.

Pfam

PF02453; Reticulon

SMART

PROSITE

PS50845; RETICULON

PRINTS