UniProt Accession

 RNH1_HUMAN; O60930; B3KQU4; O60523; O60857; Q57Z93; Q5U0C1; Q6FHD4 

Genbank Protein ID

 AF048995; AF048994; AF039652; AJ224117; CR541820; BT019670; AK075490; AC108488; CH471053; BC002973 

Genbank Nucleotide ID

 AAC78564.1; AAC78563.1; AAC09261.1; CAA11835.1; CAG46619.1; AAV38476.1; BAG52156.1; AAX82026.1; EAX01061.1; AAH02973.1 

Protein Name

 Ribonuclease H1 

Protein Synonyms/Alias

 RNase H1; Ribonuclease H type II 

Gene Name

 RNASEH1 

Gene Synonyms/Alias

 RNH1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	RFPAARFKKFATEDE	ubiquitination	[1]
60	FPAARFKKFATEDEA	ubiquitination	[1]
73	EAWAFVRKSASPEVS	ubiquitination	[1]
119	EPYAKHMKPSVEPAP	ubiquitination	[1]
192	AEIHAACKAIEQAKT	ubiquitination	[1, 2]
198	CKAIEQAKTQNINKL	ubiquitination	[1]
241	AGKEVINKEDFVALE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids. 

Sequence Annotation

 DOMAIN 136 282 RNase H.
 METAL 145 145 Magnesium 1 (By similarity).
 METAL 145 145 Magnesium 2 (By similarity).
 METAL 186 186 Magnesium 1 (By similarity).
 METAL 210 210 Magnesium 1 (By similarity).
 METAL 274 274 Magnesium 2 (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 286 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004540; F:ribonuclease activity; TAS:ProtInc.
 GO:0004523; F:ribonuclease H activity; IEA:EC.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0006401; P:RNA catabolic process; TAS:ProtInc. 

Interpro

 IPR009027; Ribosomal_L9/RNase_H1_N.
 IPR017067; RNase_H1_euk.
 IPR011320; RNase_H1_N.
 IPR012337; RNaseH-like_dom.
 IPR002156; RNaseH_domain. 

Pfam

 PF01693; Cauli_VI
 PF00075; RNase_H 

SMART

  

PROSITE

 PS50879; RNASE_H 

PRINTS