UniProt Accession

 NUP60_YEAST; P39705; D6VPL6 

Genbank Protein ID

 L22015; AY692943; BK006935 

Genbank Nucleotide ID

 AAC04957.1; AAT92962.1; DAA06986.1 

Protein Name

 Nucleoporin NUP60 

Protein Synonyms/Alias

 Nuclear pore protein NUP60 

Gene Name

 NUP60 

Gene Synonyms/Alias

 FUN17; YAR002W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
161	ITSEGEQKSAEGNNI	ubiquitination	[1]
358	ISPSAPSKDSFTKYK	acetylation	[2]
447	KPKTELTKGDSTPVQ	acetylation	[2]
467	TPQKSSSKGFVFNSV	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). 

Sequence Annotation

 REPEAT 399 401 FXF 1.
 REPEAT 427 429 FXF 2.
 REPEAT 469 471 FXF 3.
 REPEAT 509 511 FXF 4.
 MOD_RES 10 10 Phosphoserine.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 81 81 Phosphoserine.
 MOD_RES 89 89 Phosphoserine.
 MOD_RES 162 162 Phosphoserine.
 MOD_RES 171 171 Phosphoserine.
 MOD_RES 214 214 Phosphoserine.
 MOD_RES 222 222 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 360 360 Phosphoserine; by CHEK2.
 MOD_RES 374 374 Phosphoserine.
 MOD_RES 382 382 Phosphoserine.
 MOD_RES 460 460 Phosphothreonine.
 MOD_RES 483 483 Phosphoserine.  

Keyword

 Coiled coil; Complete proteome; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 539 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0044613; C:nuclear pore central transport channel; IDA:SGD.
 GO:0044615; C:nuclear pore nuclear basket; IDA:SGD.
 GO:0005487; F:nucleocytoplasmic transporter activity; IGI:SGD.
 GO:0005543; F:phospholipid binding; IDA:SGD.
 GO:0017056; F:structural constituent of nuclear pore; IMP:SGD.
 GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:SGD.
 GO:0006302; P:double-strand break repair; IMP:SGD.
 GO:0008298; P:intracellular mRNA localization; IMP:SGD.
 GO:0031990; P:mRNA export from nucleus in response to heat stress; IMP:SGD.
 GO:0006607; P:NLS-bearing substrate import into nucleus; IMP:SGD.
 GO:0016973; P:poly(A)+ mRNA export from nucleus; IMP:SGD.
 GO:0000973; P:posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IMP:SGD.
 GO:0006611; P:protein export from nucleus; IMP:SGD.
 GO:0060188; P:regulation of protein desumoylation; IGI:SGD.
 GO:0034398; P:telomere tethering at nuclear periphery; IMP:SGD. 

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PRINTS