UniProt Accession

 KES1_YEAST; P35844; D6W3M4; E9P8U8 

Genbank Protein ID

 U03913; U43703; X96770; Z73501; AY558047; BK006949 

Genbank Nucleotide ID

 AAA17736.1; AAB68217.1; CAA65548.1; CAA97849.1; AAS56373.1; DAA11290.1 

Protein Name

 Protein KES1 

Protein Synonyms/Alias

 Oxysterol-binding protein homolog 4 

Gene Name

 KES1 

Gene Synonyms/Alias

 OSH4; YPL145C; LPI3C; P2614 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
109	ESLGSEKKPLNPFLG	acetylation	[1]
109	ESLGSEKKPLNPFLG	ubiquitination	[2]
160	FNDKNKVKLQGYNQI	ubiquitination	[2]
168	LQGYNQIKASFTKSL	acetylation	[1]
315	QHPLESRKAWYDVAG	ubiquitination	[2]
336	FNLIAKTKTELEETQ	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Plays a role in ergosterol synthesis. 

Sequence Annotation

 MOD_RES 370 370 Phosphothreonine.
 MOD_RES 389 389 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Lipid biosynthesis; Lipid metabolism; Phosphoprotein; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 434 AA 

Protein Sequence

Gene Ontology

 GO:0019898; C:extrinsic to membrane; IDA:SGD.
 GO:0000139; C:Golgi membrane; IDA:SGD.
 GO:0008142; F:oxysterol binding; IMP:SGD.
 GO:0070300; F:phosphatidic acid binding; IDA:SGD.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IMP:SGD.
 GO:0070273; F:phosphatidylinositol-4-phosphate binding; IDA:SGD.
 GO:0015248; F:sterol transporter activity; IDA:SGD.
 GO:0006897; P:endocytosis; IGI:SGD.
 GO:0006887; P:exocytosis; IGI:SGD.
 GO:0030011; P:maintenance of cell polarity; IGI:SGD.
 GO:0010922; P:positive regulation of phosphatase activity; IDA:SGD.
 GO:0006892; P:post-Golgi vesicle-mediated transport; IGI:SGD.
 GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR000648; Oxysterol-bd.
 IPR018494; Oxysterol-bd_CS. 

Pfam

 PF01237; Oxysterol_BP 

SMART

  

PROSITE

 PS01013; OSBP 

PRINTS