| Tag | Content |
|---|
| CPLM ID | CPLM-010470 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase N2 |
Protein Synonyms/Alias | R-PTP-N2; PTP IA-2beta; Protein tyrosine phosphatase-NP; PTP-NP |
Gene Name | Ptprn2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 636 | SHYKLKDKLSGLGAD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Implicated in development of nervous system and pancreatic endocrine cells. |
Sequence Annotation | DOMAIN 731 991 Tyrosine-protein phosphatase.
REGION 931 937 Substrate binding (By similarity).
ACT_SITE 931 931 Phosphocysteine intermediate (Potential).
BINDING 899 899 Substrate (By similarity).
BINDING 976 976 Substrate (By similarity).
MOD_RES 678 678 Phosphoserine.
MOD_RES 956 956 N6-acetyllysine (By similarity).
CARBOHYD 550 550 N-linked (GlcNAc...) (Potential). |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasmic vesicle; Diabetes mellitus; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Protein phosphatase; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1001 AA |
Protein Sequence | MGPPLPLLLL LLLPPPLPRA LPAPASARGR QLPGRLGCLF EDGLCGSLET CVNDGVFGRC 60
QKVPVMDTYR YEVPPGALLH LKVTLQKLSR TGFTWQDDYT QRVIAQELAN LPKAYLWHGE 120
ASGPARSLQQ NADNEKWFSL EREVALAKTL RRYLPYLELL SQTPTANAHS RIDHETRPAK 180
GEDSSPENIL TYVAHTSALT YPPATRAKYP DNLLRPFSRL QPDELSPKVD GDIDKQKLIA 240
ALGAYTAQRL PGENDPEPRY LVHGSARAPR PFSATALSQR WPPPPGDAKD SPSMDDDTLL 300
QSLLKDLQQN SEVDRLGPLK EEKADSVAGA IQSDPAEGSQ ESHGRGAEGQ PREQTDAPET 360
MLQDHRLSEV DDPVYKEVNR LSFQLGDLLK DYGSPLLPEG PLLEKSSREE IKKSEQPEEV 420
LSSEEETAGV EHVRSRTYSK DLFERKPNSE PQPRRLEDQF QNRAPELWED EESLKLAAQG 480
PPSGGLQLEV QPSEEQQGYI LTGNNPLSPE KGKQLMDQVA HILRVPSSFF ADIKVLGPAV 540
TFKVSANIQN MTTADVIKAA ADNKDQLEKA TGLTILQSGI RPKGKLKLLP HQEEQEDSTK 600
FILLTFLSIA CILGVLLASS LAYCLRHNSH YKLKDKLSGL GADPSADATE AYQELCRQRM 660
AIRPQDRSEG PHTSRINSVS SQFSDGPMPS PSARSSTSSW SEEPVQSNMD ISTGHMILAY 720
MEDHLKNKNR LEKEWEALCA YQAEPNSSLV AQREENAPKN RSLAVLTYDH SRILLKSQNS 780
HGSSDYINAS PIMDHDPRNP AYIATQGPLP ATVADFWQMV WESGCAVIVM LTPLSENGVR 840
QCHHYWPDEG SNLYHVYEVN LVSEHIWCQD FLVRSFYLKN LQTNETRTVT QFHFLSWYDQ 900
GVPSSTRSLL DFRRKVNKCY RGRSCPIIVH CSDGAGRSGT YVLIDMVLNK MAKGAKEIDI 960
AATLEHLRDQ RPGMVQTKEQ FEFALTAVAE EVNAILKALP Q 1001 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0030141; C:secretory granule; IDA:MGI. GO:0043195; C:terminal bouton; IEA:Compara. GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell. GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. GO:0034260; P:negative regulation of GTPase activity; IEA:Compara. GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |