CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044916
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Periplakin 
Protein Synonyms/Alias
  
Gene Name
 PPL 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
371DQEKVLDKYEDVVQGubiquitination[1]
381DVVQGLQKRGQQVVPubiquitination[1]
490QQRYEVLKTENPGDAubiquitination[1, 2]
548AERAKDLKNITNELLubiquitination[1, 2]
805DYELEAEKLRSLLDLubiquitination[2]
1141QYEDEAAKARASQREubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1754 AA 
Protein Sequence
MNSLFRKRNK GKYSPTVQTR SISNKELSEL IEQLQKNADQ VEKNIVDTEA KMQSDLARLQ 60
EGRQPEHRDV TLQKVLDSEK LLYVLEADAA IAKHMKHPQG DMIAEDIRQL KERVTNLRGK 120
HKQIYRLAVK EVDPQVNWAA LVEEKLDKLN NQSFGTDLPL VDHQVEEHNI FHNEVKAIGP 180
HLAKDGDKNS ELRAKYQKLL AASQARQQHL SSLQDYMQRC TNELYWLDQQ AKGRMQYDWS 240
DRNLDYPSRR RQYENFINRN LEAKEERINK LHSEGDQLLA AEHPGRNSIE AHMEAVHADW 300
KEYLNLLICE ESHLKYMEDY HQFHEDVKDA QELLRKVDSD LNQKYGPDFK DRYQIELLLR 360
ELDDQEKVLD KYEDVVQGLQ KRGQQVVPLK YRRETPLKPI PVEALCDFEG EQGLISRGYS 420
YTLQKNNGES WELMDSAGNK LIAPAVCFVI PPTDPEALAL ADSLGSQYRS VRQKAAGSKR 480
TLQQRYEVLK TENPGDASDL QGRQLLAGLD KVASDLDRQE KAITGILRPP LEQGRAVQDS 540
AERAKDLKNI TNELLRIEPE KTRSTAEGEA FIQALPGSGT TPLLRTRVED TNRKYEHLLQ 600
LLDLAQEKVD VANRLEKSLQ QSWELLATHE NHLNQDDTVP ESSRVLDSKG QELAAMACEL 660
QAQKSLLGEV EQNLQAAKQC SSTLASRFQE HCPDLERQEA EVHKLGQRFN NLRQQVERRA 720
QSLQSAKAAY EHFHRGHDHV LQFLVSIPSY EPQETDSLSQ METKLKNQKN LLDEIASREQ 780
EVQKICANSQ QYQQAVKDYE LEAEKLRSLL DLENGRRSHV SKRARLQSPA TKVKEEEAAL 840
AAKFTEVYAI NRQRLQNLEF ALNLLRQQPE VEVTHETLQR NRPDSGVEEA WKIRKELDEE 900
TERRRQLENE VKSTQEEIWT LRNQGPQESV VRKEVLKKVP DPVLEESFQQ LQRTLAEEQH 960
KNQLLQEELE ALQLQLRALE QETRDGGQEY VVKEVLRIEP DRAQADEVLQ LREELEALRR 1020
QKGAREAEVL LLQQRVAALA EEKSRAQEKV TEKEVVKLQN DPQLEAEYQQ LQEDHQRQDQ 1080
LREKQEEELS FLQDKLKRLE KERAMAEGKI TVKEVLKVEK DAATEREVSD LTRQYEDEAA 1140
KARASQREKT ELLRKIWALE EENAKVVVQE KVREIVRPDP KAESEVANLR LELVEQERKY 1200
RGAEEQLRSY QSELEALRRR GPQVEVKEVT KEVIKYKTDP EMEKELQRLR EEIVDKTRLI 1260
ERCDLEIYQL KKEIQALKDT KPQVQTKEVV QEILQFQEDP QTKEEVASLR AKLSEEQKKQ 1320
VDLERERASQ EEQIARKEEE LSRVKERVVQ QEVVRYEEEP GLRAEASAFA ESIDVELRQI 1380
DKLRAELRRL QRRRTELERQ LEELERERQA RREAEREVQR LQQRLAALEQ EEAEAREKVT 1440
HTQKVVLQQD PQQAREHALL RLQLEEEQHR RQLLEGELET LRRKLAALEK AEVKEKVVLS 1500
ESVQVEKGDT EQEIQRLKSS LEEESRSKRE LDVEVSRLEA RLSELEFHNS KSSKELDFLR 1560
EENHKLQLER QNLQLETRRL QSEINMAATE TRDLRNMTVA DSGTNHDSRL WSLERELDDL 1620
KRLSKDKDLE IDELQKRLGS VAVKREQREN HLRRSIVVIH PDTGRELSPE EAHRAGLIDW 1680
NMFVKLRSQE CDWEEISVKG PNGESSVIHD RKSGKKFSIE EALQSGRLTP AQYDRYVNKD 1740
MSIQELAVLV SGQK 1754 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro. 
Interpro
 IPR001101; Plectin_repeat.
 IPR018159; Spectrin/alpha-actinin. 
Pfam
 PF00681; Plectin 
SMART
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
  
PRINTS