UniProt Accession

 3BHS1_RAT; P22071; Q19P43 

Genbank Protein ID

 M38178; BC086578; DQ515797 

Genbank Nucleotide ID

 AAA63474.1; AAH86578.1; ABF70960.1 

Protein Name

 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 

Protein Synonyms/Alias

 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta-5-3-ketosteroid isomerase 

Gene Name

 Hsd3b1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
350	LVSWEEAKQKTSEWI	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. 

Sequence Annotation

 ACT_SITE 155 155 Proton acceptor (By similarity).
 BINDING 159 159 NAD (By similarity).  

Keyword

 Complete proteome; Endoplasmic reticulum; Isomerase; Membrane; Mitochondrion; Multifunctional enzyme; NAD; Oxidoreductase; Reference proteome; Steroidogenesis; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 373 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030061; C:mitochondrial crista; IDA:RGD.
 GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IDA:RGD.
 GO:0035410; F:dihydrotestosterone 17-beta-dehydrogenase activity; IDA:RGD.
 GO:0051287; F:NAD binding; IDA:RGD.
 GO:0005496; F:steroid binding; IPI:RGD.
 GO:0004769; F:steroid delta-isomerase activity; IDA:RGD.
 GO:0030325; P:adrenal gland development; IEP:RGD.
 GO:0018879; P:biphenyl metabolic process; IEP:RGD.
 GO:0071236; P:cellular response to antibiotic; IEP:RGD.
 GO:0071320; P:cellular response to cAMP; IEP:RGD.
 GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
 GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEP:RGD.
 GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEP:RGD.
 GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
 GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD.
 GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.
 GO:0071373; P:cellular response to luteinizing hormone stimulus; IEP:RGD.
 GO:0071288; P:cellular response to mercury ion; IEP:RGD.
 GO:0071406; P:cellular response to methylmercury; IEP:RGD.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD.
 GO:0018894; P:dibenzo-p-dioxin metabolic process; IEP:RGD.
 GO:0016101; P:diterpenoid metabolic process; IEP:RGD.
 GO:0006703; P:estrogen biosynthetic process; IEP:RGD.
 GO:0008585; P:female gonad development; IEP:RGD.
 GO:0050756; P:fractalkine metabolic process; IEP:RGD.
 GO:0030851; P:granulocyte differentiation; IEP:RGD.
 GO:0021766; P:hippocampus development; IEP:RGD.
 GO:0017143; P:insecticide metabolic process; IEP:RGD.
 GO:0033327; P:Leydig cell differentiation; IEP:RGD.
 GO:0060135; P:maternal process involved in female pregnancy; IEP:RGD.
 GO:0006082; P:organic acid metabolic process; IEP:RGD.
 GO:0030728; P:ovulation; IEP:RGD.
 GO:0018958; P:phenol-containing compound metabolic process; IEP:RGD.
 GO:0046470; P:phosphatidylcholine metabolic process; IEP:RGD.
 GO:0006701; P:progesterone biosynthetic process; IDA:RGD.
 GO:0014823; P:response to activity; IEP:RGD.
 GO:0043279; P:response to alkaloid; IEP:RGD.
 GO:0046685; P:response to arsenic-containing substance; IEP:RGD.
 GO:0046686; P:response to cadmium ion; IEP:RGD.
 GO:0051592; P:response to calcium ion; IEP:RGD.
 GO:0051412; P:response to corticosterone stimulus; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0070542; P:response to fatty acid; IEP:RGD.
 GO:0060992; P:response to fungicide; IEP:RGD.
 GO:0009635; P:response to herbicide; IEP:RGD.
 GO:0033591; P:response to L-ascorbic acid; IEP:RGD.
 GO:0010288; P:response to lead ion; IEP:RGD.
 GO:0010226; P:response to lithium ion; IEP:RGD.
 GO:0033197; P:response to vitamin E; IEP:RGD.
 GO:0061370; P:testosterone biosynthetic process; IEP:RGD.
 GO:0018970; P:toluene metabolic process; IEP:RGD. 

Interpro

 IPR002225; 3Beta_OHSteriod_DH/Estase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01073; 3Beta_HSD 

SMART

  

PROSITE

  

PRINTS