UniProt Accession

 ERG24_HUMAN; O76062; A8K4H0; O95982; Q8IY06; Q96E64; Q96GZ1 

Genbank Protein ID

 AF048704; AF023676; AF096303; AF096304; AK290935; BC009052; BC012857; BC038353 

Genbank Nucleotide ID

 AAC21457.1; AAC21450.1; AAD09769.1; AAD09765.1; BAF83624.1; AAH09052.1; AAH12857.1; AAH38353.1 

Protein Name

 Delta(14)-sterol reductase 

Protein Synonyms/Alias

 Delta-14-SR; Another new gene 1 protein; C-14 sterol reductase; Putative sterol reductase SR-1; Sterol C14-reductase; Transmembrane 7 superfamily member 2 

Gene Name

 TM7SF2 

Gene Synonyms/Alias

 ANG1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
91	VAEGQELKDKSRLRY	ubiquitination	[1]
311	FRGANSQKNTFRKNP	ubiquitination	[2]
397	DERQCLQKYGLAWQE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Involved in the conversion of lanosterol to cholesterol. 

Sequence Annotation

  

Keyword

 Alternative splicing; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane; Microsome; NADP; Oxidoreductase; Polymorphism; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 418 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0050613; F:delta14-sterol reductase activity; IEA:EC.
 GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome. 

Interpro

 IPR001171; Ergosterol_biosynth_ERG4_ERG24.
 IPR018083; Sterol_reductase_CS. 

Pfam

 PF01222; ERG4_ERG24 

SMART

  

PROSITE

 PS01017; STEROL_REDUCT_1
 PS01018; STEROL_REDUCT_2 

PRINTS